Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7975
MIM: 600197
HGNC: 6782
Ensembl: ENSG00000198517
Variants:
dbSNP: 7975
ClinVar: 7975
TCGA: ENSG00000198517
COSMIC: MAFK
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Hemostasis | REACTOME | R-HSA-109582 |
| Factors involved in megakaryocyte development and platelet production | REACTOME | R-HSA-983231 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164925725 | Toxic liver disease | Disease | ClinicalAnnotation | associated | PD | 22341855, 29036176 | |
| PA166119041 | drug-induced liver injury | Disease | ClinicalAnnotation | associated | PD | 22341855, 29036176 | |
| PA283 | MAPK8 | Gene | Pathway | associated | 23922006 | ||
| PA30621 | MAPK14 | Gene | Pathway | associated | 23922006 | ||
| PA450112 | isoniazid | Chemical | ClinicalAnnotation | associated | PD | 22341855, 29036176 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35260530 | 2022 | MafK accelerates Salmonella mucosal infection through caspase-3 activation. | 2 |
| 35260530 | 2022 | MafK accelerates Salmonella mucosal infection through caspase-3 activation. | 2 |
| 33877894 | 2021 | MAFK Polymorphisms Located in 3'-UTR are Associated with Severity of Atrophy and CDKN2A Methylation Status in the Gastric Mucosa. | 0 |
| 33877894 | 2021 | MAFK Polymorphisms Located in 3'-UTR are Associated with Severity of Atrophy and CDKN2A Methylation Status in the Gastric Mucosa. | 0 |
| 28400538 | 2017 | The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB. | 40 |
| 28839436 | 2017 | Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan. | 2 |
| 28400538 | 2017 | The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB. | 40 |
| 28839436 | 2017 | Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan. | 2 |
| 26214410 | 2015 | Wnt1-induced MAFK expression promotes osteosarcoma cell proliferation. | 8 |
| 26214410 | 2015 | Wnt1-induced MAFK expression promotes osteosarcoma cell proliferation. | 8 |
| 23737527 | 2013 | Transforming growth factor-β induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene. | 28 |
| 24232097 | 2013 | Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis. | 27 |
| 24247732 | 2013 | MafK positively regulates NF-κB activity by enhancing CBP-mediated p65 acetylation. | 29 |
| 23737527 | 2013 | Transforming growth factor-β induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene. | 28 |
| 24232097 | 2013 | Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis. | 27 |
Citation
Dessen P
MAFK (MAF bZIP transcription factor K)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41239/mafk-(maf-bzip-transcription-factor-k)
