MAGED1 (MAGE family member D1)

2003-06-01  

Identity

HGNC
MAGED1
LOCATION
Xp11.22
LOCUSID
9500
ALIAS
DLXIN-1,NRAGE
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9500
MIM: 300224
HGNC: 6813
Ensembl: ENSG00000179222

Variants:

dbSNP: 9500
ClinVar: 9500
TCGA: ENSG00000179222
COSMIC: MAGED1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179222ENST00000326587Q9Y5V3
ENSG00000179222ENST00000375695Q9Y5V3
ENSG00000179222ENST00000375722Q9Y5V3
ENSG00000179222ENST00000375772Q9Y5V3

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Caspase activation via extrinsic apoptotic signalling pathwayREACTOMER-HSA-5357769
Ligand-independent caspase activation via DCCREACTOMER-HSA-418889

References

Pubmed IDYearTitleCitations
319168452020Knockdown of NRAGE Impairs Homologous Recombination Repair and Sensitizes Hepatoblastoma Cells to Ionizing Radiation.3
319168452020Knockdown of NRAGE Impairs Homologous Recombination Repair and Sensitizes Hepatoblastoma Cells to Ionizing Radiation.3
295169582018The role of NRAGE subcellular location and epithelial-mesenchymal transition on radiation resistance of esophageal carcinoma cell.5
297784242018NRAGE confers poor prognosis and promotes proliferation, invasion, and chemoresistance in gastric cancer.5
305089432018NRAGE is a potential diagnostic biomarker of hepatocellular carcinoma.2
295169582018The role of NRAGE subcellular location and epithelial-mesenchymal transition on radiation resistance of esophageal carcinoma cell.5
297784242018NRAGE confers poor prognosis and promotes proliferation, invasion, and chemoresistance in gastric cancer.5
305089432018NRAGE is a potential diagnostic biomarker of hepatocellular carcinoma.2
284147752017Xp11.22 deletions encompassing CENPVL1, CENPVL2, MAGED1 and GSPT2 as a cause of syndromic X-linked intellectual disability.7
284279392017NRAGE induces β-catenin/Arm O-GlcNAcylation and negatively regulates Wnt signaling.3
286399092017Silencing of NRAGE induces autophagy via AMPK/Ulk1/Atg13 signaling pathway in NSCLC cells.3
284147752017Xp11.22 deletions encompassing CENPVL1, CENPVL2, MAGED1 and GSPT2 as a cause of syndromic X-linked intellectual disability.7
284279392017NRAGE induces β-catenin/Arm O-GlcNAcylation and negatively regulates Wnt signaling.3
286399092017Silencing of NRAGE induces autophagy via AMPK/Ulk1/Atg13 signaling pathway in NSCLC cells.3
267388702016Identification of novel NRAGE involved in the radioresistance of esophageal cancer cells.8

Citation

Dessen P

MAGED1 (MAGE family member D1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41261