MAP2K2 (mitogen-activated protein kinase kinase 2)

2003-11-01

Identity

HGNC

MAP2K2

LOCATION

19p13.3

LOCUSID

5605

ALIAS

CFC4,MAPKK2,MEK2,MKK2,PRKMK2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5605
MIM: 601263
HGNC: 6842
Ensembl: ENSG00000126934

Variants:

dbSNP: 5605
ClinVar: 5605
TCGA: ENSG00000126934
COSMIC: MAP2K2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000126934	ENST00000262948	P36507
ENSG00000126934	ENST00000394867	G5E9C7
ENSG00000126934	ENST00000599021	M0R1B6

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Acute myeloid leukemia	KEGG	ko05221
Acute myeloid leukemia	KEGG	hsa05221
Apelin signaling pathway	KEGG	hsa04371
Apoptosis	KEGG	ko04210
Apoptosis	KEGG	hsa04210
ARMS-mediated activation	REACTOME	R-HSA-170984
Autophagy - animal	KEGG	ko04140
Autophagy - animal	KEGG	hsa04140
Axon guidance	REACTOME	R-HSA-422475
B cell receptor signaling pathway	KEGG	ko04662

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA24928	ARAF	Gene	Pathway	associated
PA25408	BRAF	Gene	Pathway	associated	28362716
PA283	MAPK8	Gene	Pathway	associated	20124951
PA30616	MAPK1	Gene	Pathway	associated	20124951, 28362716
PA30617	MAPK10	Gene	Pathway	associated	20124951
PA30618	MAPK11	Gene	Pathway	associated	20124951
PA30619	MAPK12	Gene	Pathway	associated	20124951
PA30620	MAPK13	Gene	Pathway	associated	20124951
PA30621	MAPK14	Gene	Pathway	associated	20124951
PA30622	MAPK3	Gene	Pathway	associated	20124951, 28362716

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References

Pubmed ID	Year	Title	Citations
33226073	2021	O-GlcNAcylation of MEK2 promotes the proliferation and migration of breast cancer cells.	4
33226073	2021	O-GlcNAcylation of MEK2 promotes the proliferation and migration of breast cancer cells.	4
33839686	2021	MEK1/2 activity modulates TREM2 cell surface recruitment.	3
33839686	2021	MEK1/2 activity modulates TREM2 cell surface recruitment.	3
34026451	2021	Dual Inhibition of DKC1 and MEK1/2 Synergistically Restrains the Growth of Colorectal Cancer Cells.	24
34026451	2021	Dual Inhibition of DKC1 and MEK1/2 Synergistically Restrains the Growth of Colorectal Cancer Cells.	24
34715128	2021	The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation.	14
34715128	2021	The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation.	14
35069558	2021	The Predictive Value of MAP2K1/2 Mutations on Efficiency of Immunotherapy in Melanoma.	7
35075244	2022	YTHDF2 promotes multiple myeloma cell proliferation via STAT5A/MAP2K2/p-ERK axis.	20

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Citation

Dessen P

MAP2K2 (mitogen-activated protein kinase kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41271/map2k2-(mitogen-activated-protein-kinase-kinase-2)