MAP2K3 (mitogen-activated protein kinase kinase 3)

2003-05-01 Affiliation

Identity

HGNC

MAP2K3

LOCATION

17p11.2

LOCUSID

5606

ALIAS

MAPKK3,MEK3,MKK3,PRKMK3,SAPKK-2,SAPKK2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5606
MIM: 602315
HGNC: 6843
Ensembl: ENSG00000034152

Variants:

dbSNP: 5606
ClinVar: 5606
TCGA: ENSG00000034152
COSMIC: MAP2K3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000034152	ENST00000316920	P46734
ENSG00000034152	ENST00000342679	P46734
ENSG00000034152	ENST00000342679	Q6FI23
ENSG00000034152	ENST00000361818	P46734
ENSG00000034152	ENST00000395491	X6RB39
ENSG00000034152	ENST00000479129	J3QL77
ENSG00000034152	ENST00000483928	J3QL77
ENSG00000034152	ENST00000496046	J3QR49
ENSG00000034152	ENST00000526076	E9PRZ0
ENSG00000034152	ENST00000527123	J3KRV4
ENSG00000034152	ENST00000529517	E9PMA8
ENSG00000034152	ENST00000613338	P46734
ENSG00000034152	ENST00000627447	J3QL77

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Toll-like receptor signaling pathway	KEGG	ko04620
Fc epsilon RI signaling pathway	KEGG	ko04664
GnRH signaling pathway	KEGG	ko04912
Amyotrophic lateral sclerosis (ALS)	KEGG	ko05014
MAPK signaling pathway	KEGG	hsa04010
Toll-like receptor signaling pathway	KEGG	hsa04620
Fc epsilon RI signaling pathway	KEGG	hsa04664
GnRH signaling pathway	KEGG	hsa04912
Amyotrophic lateral sclerosis (ALS)	KEGG	hsa05014
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
TNF signaling pathway	KEGG	hsa04668
TNF signaling pathway	KEGG	ko04668
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
MAPK (p38) signaling	KEGG	hsa_M00689
MAPK (p38) signaling	KEGG	M00689
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
Uptake and actions of bacterial toxins	REACTOME	R-HSA-5339562
Uptake and function of anthrax toxins	REACTOME	R-HSA-5210891
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 10 (TLR10) Cascade	REACTOME	R-HSA-168142
MyD88 cascade initiated on plasma membrane	REACTOME	R-HSA-975871
MAP kinase activation in TLR cascade	REACTOME	R-HSA-450294
activated TAK1 mediates p38 MAPK activation	REACTOME	R-HSA-450302
Toll Like Receptor 3 (TLR3) Cascade	REACTOME	R-HSA-168164
MyD88-independent TLR3/TLR4 cascade	REACTOME	R-HSA-166166
TRIF-mediated TLR3/TLR4 signaling	REACTOME	R-HSA-937061
Toll Like Receptor 5 (TLR5) Cascade	REACTOME	R-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) Cascade	REACTOME	R-HSA-168181
MyD88 dependent cascade initiated on endosome	REACTOME	R-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	REACTOME	R-HSA-975138
Toll Like Receptor 9 (TLR9) Cascade	REACTOME	R-HSA-168138
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
MyD88:Mal cascade initiated on plasma membrane	REACTOME	R-HSA-166058
Toll Like Receptor 2 (TLR2) Cascade	REACTOME	R-HSA-181438
Toll Like Receptor TLR1:TLR2 Cascade	REACTOME	R-HSA-168179
Toll Like Receptor TLR6:TLR2 Cascade	REACTOME	R-HSA-168188
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular Senescence	REACTOME	R-HSA-2559583
Oxidative Stress Induced Senescence	REACTOME	R-HSA-2559580

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA283	MAPK8	Gene	Pathway	associated	20124951
PA30594	MAP3K11	Gene	Pathway	associated	23922006
PA30603	MAP3K7	Gene	Pathway	associated	23922006
PA30616	MAPK1	Gene	Pathway	associated	20124951
PA30617	MAPK10	Gene	Pathway	associated	20124951
PA30618	MAPK11	Gene	Pathway	associated	20124951
PA30619	MAPK12	Gene	Pathway	associated	20124951
PA30620	MAPK13	Gene	Pathway	associated	20124951
PA30621	MAPK14	Gene	Pathway	associated	20124951, 23922006
PA30622	MAPK3	Gene	Pathway	associated	20124951
PA30623	MAPK4	Gene	Pathway	associated	20124951
PA30624	MAPK6	Gene	Pathway	associated	20124951
PA30625	MAPK7	Gene	Pathway	associated	20124951
PA30630	MAPK9	Gene	Pathway	associated	20124951
PA34183	RAF1	Gene	Pathway	associated	20124951

References

Pubmed ID	Year	Title	Citations
36870282	2023	Identification of MAP Kinase Kinase 3 as a protein target of myricetin in non-small cell lung cancer cells.	2
37713993	2023	Activated MKK3/MYC crosstalk impairs dabrafenib response in BRAFV600E colorectal cancer leading to resistance.	1
36870282	2023	Identification of MAP Kinase Kinase 3 as a protein target of myricetin in non-small cell lung cancer cells.	2
37713993	2023	Activated MKK3/MYC crosstalk impairs dabrafenib response in BRAFV600E colorectal cancer leading to resistance.	1
33660414	2021	The miR-19b-3p-MAP2K3-STAT3 feedback loop regulates cell proliferation and invasion in esophageal squamous cell carcinoma.	11
33774214	2021	Whole-Exome Sequencing Reveals Novel Variations in Patients with Familial Von Hippel-Lindau Syndrome.	0
34830095	2021	Quadruple and Truncated MEK3 Mutants Identified from Acute Lymphoblastic Leukemia Promote Degradation and Enhance Proliferation.	2
33660414	2021	The miR-19b-3p-MAP2K3-STAT3 feedback loop regulates cell proliferation and invasion in esophageal squamous cell carcinoma.	11
33774214	2021	Whole-Exome Sequencing Reveals Novel Variations in Patients with Familial Von Hippel-Lindau Syndrome.	0
34830095	2021	Quadruple and Truncated MEK3 Mutants Identified from Acute Lymphoblastic Leukemia Promote Degradation and Enhance Proliferation.	2
31634561	2020	miR-214 down-regulates MKK3 and suppresses malignant phenotypes of cervical cancer cells.	11
32429593	2020	The MKK-Dependent Phosphorylation of p38α Is Augmented by Arginine Methylation on Arg49/Arg149 during Erythroid Differentiation.	8
32747557	2020	Genome-wide RNA interference screening reveals a COPI-MAP2K3 pathway required for YAP regulation.	4
32843639	2020	TIPE-mediated up-regulation of MMP-9 promotes colorectal cancer invasion and metastasis through MKK-3/p38/NF-κB pro-oncogenic signaling pathway.	5
31634561	2020	miR-214 down-regulates MKK3 and suppresses malignant phenotypes of cervical cancer cells.	11

Citation

Dessen P

MAP2K3 (mitogen-activated protein kinase kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41272/map2k3-(mitogen-activated-protein-kinase-kinase-3)