MAP3K10 (mitogen-activated protein kinase kinase kinase 10)

2003-02-01  

Identity

HGNC
MAP3K10
LOCATION
19q13.2
LOCUSID
4294
ALIAS
MEKK10,MLK2,MST
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4294
MIM: 600137
HGNC: 6849
Ensembl: ENSG00000130758

Variants:

dbSNP: 4294
ClinVar: 4294
TCGA: ENSG00000130758
COSMIC: MAP3K10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130758ENST00000253055Q02779
ENSG00000130758ENST00000593502M0R365
ENSG00000130758ENST00000594951M0R0A7
ENSG00000130758ENST00000597986M0R1J8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK (JNK) signalingKEGGhsa_M00688
MAPK (p38) signalingKEGGhsa_M00689
MAPK (JNK) signalingKEGGM00688
MAPK (p38) signalingKEGGM00689

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
363417292023DNA methylation of the MAP3K10 gene may participate in the development of intracranial aneurysm.2
363417292023DNA methylation of the MAP3K10 gene may participate in the development of intracranial aneurysm.2
323238572020DNA methylation‑regulated miR‑155‑5p depresses sensitivity of esophageal carcinoma cells to radiation and multiple chemotherapeutic drugs via suppression of MAP3K10.3
323238572020DNA methylation‑regulated miR‑155‑5p depresses sensitivity of esophageal carcinoma cells to radiation and multiple chemotherapeutic drugs via suppression of MAP3K10.3
282142072017MicroRNA-155 targets MAP3K10 and regulates osteosarcoma cell growth.4
289477952017Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control.22
282142072017MicroRNA-155 targets MAP3K10 and regulates osteosarcoma cell growth.4
289477952017Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control.22
231784522013MAP3K10 promotes the proliferation and decreases the sensitivity of pancreatic cancer cells to gemcitabine by upregulating Gli-1 and Gli-2.11
237603662013The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1.15
231784522013MAP3K10 promotes the proliferation and decreases the sensitivity of pancreatic cancer cells to gemcitabine by upregulating Gli-1 and Gli-2.11
237603662013The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1.15
216784192012Identification of RUNX3 as a component of the MST/Hpo signaling pathway.8
216784192012Identification of RUNX3 as a component of the MST/Hpo signaling pathway.8
219799192011TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.55

Citation

Dessen P

MAP3K10 (mitogen-activated protein kinase kinase kinase 10)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41276/map3k10-(mitogen-activated-protein-kinase-kinase-kinase-10)