Identity
HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
MEKK10,MLK2,MST
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4294
MIM: 600137
HGNC: 6849
Ensembl: ENSG00000130758
Variants:
dbSNP: 4294
ClinVar: 4294
TCGA: ENSG00000130758
COSMIC: MAP3K10
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000130758 | ENST00000253055 | Q02779 |
| ENSG00000130758 | ENST00000593502 | M0R365 |
| ENSG00000130758 | ENST00000594951 | M0R0A7 |
| ENSG00000130758 | ENST00000597986 | M0R1J8 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| MAPK (JNK) signaling | KEGG | hsa_M00688 |
| MAPK (p38) signaling | KEGG | hsa_M00689 |
| MAPK (JNK) signaling | KEGG | M00688 |
| MAPK (p38) signaling | KEGG | M00689 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36341729 | 2023 | DNA methylation of the MAP3K10 gene may participate in the development of intracranial aneurysm. | 2 |
| 36341729 | 2023 | DNA methylation of the MAP3K10 gene may participate in the development of intracranial aneurysm. | 2 |
| 32323857 | 2020 | DNA methylation‑regulated miR‑155‑5p depresses sensitivity of esophageal carcinoma cells to radiation and multiple chemotherapeutic drugs via suppression of MAP3K10. | 3 |
| 32323857 | 2020 | DNA methylation‑regulated miR‑155‑5p depresses sensitivity of esophageal carcinoma cells to radiation and multiple chemotherapeutic drugs via suppression of MAP3K10. | 3 |
| 28214207 | 2017 | MicroRNA-155 targets MAP3K10 and regulates osteosarcoma cell growth. | 4 |
| 28947795 | 2017 | Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control. | 22 |
| 28214207 | 2017 | MicroRNA-155 targets MAP3K10 and regulates osteosarcoma cell growth. | 4 |
| 28947795 | 2017 | Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control. | 22 |
| 23178452 | 2013 | MAP3K10 promotes the proliferation and decreases the sensitivity of pancreatic cancer cells to gemcitabine by upregulating Gli-1 and Gli-2. | 11 |
| 23760366 | 2013 | The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1. | 15 |
| 23178452 | 2013 | MAP3K10 promotes the proliferation and decreases the sensitivity of pancreatic cancer cells to gemcitabine by upregulating Gli-1 and Gli-2. | 11 |
| 23760366 | 2013 | The TGFβ-induced phosphorylation and activation of p38 mitogen-activated protein kinase is mediated by MAP3K4 and MAP3K10 but not TAK1. | 15 |
| 21678419 | 2012 | Identification of RUNX3 as a component of the MST/Hpo signaling pathway. | 8 |
| 21678419 | 2012 | Identification of RUNX3 as a component of the MST/Hpo signaling pathway. | 8 |
| 21979919 | 2011 | TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway. | 55 |
Citation
Dessen P
MAP3K10 (mitogen-activated protein kinase kinase kinase 10)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41276/map3k10-(mitogen-activated-protein-kinase-kinase-kinase-10)
