MAP3K11 (mitogen-activated protein kinase kinase kinase 11)

2003-02-01

Identity

HGNC

MAP3K11

LOCATION

11q13.1

LOCUSID

4296

ALIAS

MEKK11,MLK-3,MLK3,PTK1,SPRK

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4296
MIM: 600050
HGNC: 6850
Ensembl: ENSG00000173327

Variants:

dbSNP: 4296
ClinVar: 4296
TCGA: ENSG00000173327
COSMIC: MAP3K11

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000173327	ENST00000309100	Q16584
ENSG00000173327	ENST00000309100	A0A024R5E6
ENSG00000173327	ENST00000524848	H0YCF5
ENSG00000173327	ENST00000526293	E9PRQ2
ENSG00000173327	ENST00000529839	E9PLB1
ENSG00000173327	ENST00000530153	Q16584
ENSG00000173327	ENST00000532507	E9PID4

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Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
ARMS-mediated activation	REACTOME	R-HSA-170984
Axon guidance	REACTOME	R-HSA-422475
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
Developmental Biology	REACTOME	R-HSA-1266738
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Downstream signal transduction	REACTOME	R-HSA-186763
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA30588	MAP2K3	Gene	Pathway	associated			23922006
PA30591	MAP2K6	Gene	Pathway	associated			23922006

References

Pubmed ID	Year	Title	Citations
33875576	2021	LATS1 Regulates Mixed-Lineage Kinase 3 (MLK3) Subcellular Localization and MLK3-Mediated Invasion in Ovarian Epithelial Cells.	2
35307409	2022	Mechanisms underlying melanoma invasion as a consequence of MLK3 loss.	0
35307409	2022	Mechanisms underlying melanoma invasion as a consequence of MLK3 loss.	0
35843311	2022	Phosphorylation of mixed lineage kinase MLK3 by cyclin-dependent kinases CDK1 and CDK2 controls ovarian cancer cell division.	0
35843311	2022	Phosphorylation of mixed lineage kinase MLK3 by cyclin-dependent kinases CDK1 and CDK2 controls ovarian cancer cell division.	0
36038020	2022	The role of mixed lineage kinase 3 (MLK3) in cancers.	1
36038020	2022	The role of mixed lineage kinase 3 (MLK3) in cancers.	1
36103355	2022	MAP3K11 facilitates autophagy activity and is correlated with malignancy of oral squamous cell carcinoma.	3
36103355	2022	MAP3K11 facilitates autophagy activity and is correlated with malignancy of oral squamous cell carcinoma.	3
36142785	2022	MLK3 Regulates Inflammatory Response via Activation of AP-1 Pathway in HEK293 and RAW264.7 Cells.	2

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Citation

Dessen P

MAP3K11 (mitogen-activated protein kinase kinase kinase 11)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41277/map3k11-(mitogen-activated-protein-kinase-kinase-kinase-11)