Identity
HGNC
LOCATION
12q13.13
LOCUSID
ALIAS
DLK,MEKK12,MUK,ZPK,ZPKP1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7786
MIM: 600447
HGNC: 6851
Ensembl: ENSG00000139625
Variants:
dbSNP: 7786
ClinVar: 7786
TCGA: ENSG00000139625
COSMIC: MAP3K12
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 30009782 | 2018 | Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12. | 23 |
| 30009782 | 2018 | Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12. | 23 |
| 28641113 | 2017 | Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons. | 74 |
| 28641113 | 2017 | Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons. | 74 |
| 27100796 | 2016 | Regulation of Beta-Cell Function and Mass by the Dual Leucine Zipper Kinase. | 2 |
| 27100796 | 2016 | Regulation of Beta-Cell Function and Mass by the Dual Leucine Zipper Kinase. | 2 |
| 25341110 | 2015 | Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. | 30 |
| 25999017 | 2015 | MicroRNA-130a Targets MAP3K12 to Modulate Diabetic Endothelial Progenitor Cell Function. | 11 |
| 25341110 | 2015 | Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. | 30 |
| 25999017 | 2015 | MicroRNA-130a Targets MAP3K12 to Modulate Diabetic Endothelial Progenitor Cell Function. | 11 |
| 21526495 | 2011 | Assessment of the pathway of apoptosis involving PAR-4, DAXX and ZIPK proteins in CLL patients and its relationship with the principal prognostic factors. | 3 |
| 21893036 | 2011 | Loss of DLK expression in WI-38 human diploid fibroblasts induces a senescent-like proliferation arrest. | 6 |
| 21526495 | 2011 | Assessment of the pathway of apoptosis involving PAR-4, DAXX and ZIPK proteins in CLL patients and its relationship with the principal prognostic factors. | 3 |
| 21893036 | 2011 | Loss of DLK expression in WI-38 human diploid fibroblasts induces a senescent-like proliferation arrest. | 6 |
| 19675578 | 2010 | The small heat-shock protein Hsp27 undergoes ERK-dependent phosphorylation and redistribution to the cytoskeleton in response to dual leucine zipper-bearing kinase expression. | 17 |
Citation
Dessen P
MAP3K12 (mitogen-activated protein kinase kinase kinase 12)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41278/map3k12-(mitogen-activated-protein-kinase-kinase-kinase-12)
