MAP3K14 (mitogen-activated protein kinase kinase kinase 14)

2003-06-01  

Identity

HGNC
LOCATION
17q21.31
LOCUSID
ALIAS
FTDCR1B,HS,HSNIK,NIK
FUSION GENES

Other Information

Locus ID:

NCBI: 9020
MIM: 604655
HGNC: 6853
Ensembl: ENSG00000006062

Variants:

dbSNP: 9020
ClinVar: 9020
TCGA: ENSG00000006062
COSMIC: MAP3K14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000006062ENST00000344686Q99558
ENSG00000006062ENST00000376926Q99558
ENSG00000006062ENST00000617331A0A087WXF1

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
ApoptosisKEGGko04210
T cell receptor signaling pathwayKEGGko04660
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
MAPK signaling pathwayKEGGhsa04010
ApoptosisKEGGhsa04210
T cell receptor signaling pathwayKEGGhsa04660
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Costimulation by the CD28 familyREACTOMER-HSA-388841
CD28 co-stimulationREACTOMER-HSA-389356
CD28 dependent PI3K/Akt signalingREACTOMER-HSA-389357
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
CLEC7A (Dectin-1) signalingREACTOMER-HSA-5607764
Dectin-1 mediated noncanonical NF-kB signalingREACTOMER-HSA-5607761
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayREACTOMER-HSA-5676594
NIK-->noncanonical NF-kB signalingREACTOMER-HSA-5676590

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
150846082004Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation.180
243629352014Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma.89
221053652012MicroRNA-520e suppresses growth of hepatoma cells by targeting the NF-κB-inducing kinase (NIK).50
205019372010Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation.47
212734892011Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation.45
152521292004Cytosolic, nuclear and nucleolar localization signals determine subcellular distribution and activity of the NF-kappaB inducing kinase NIK.36
160097132005Interferon induces NF-kappa B-inducing kinase/tumor necrosis factor receptor-associated factor-dependent NF-kappa B activation to promote cell survival.33
254065812014Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity.33
224691342012Genetic lesions of the TRAF3 and MAP3K14 genes in classical Hodgkin lymphoma.31
203480962010Allosteric regulation of the ubiquitin:NIK and ubiquitin:TRAF3 E3 ligases by the lymphotoxin-beta receptor.30

Citation

Dessen P

MAP3K14 (mitogen-activated protein kinase kinase kinase 14)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41279/map3k14-(mitogen-activated-protein-kinase-kinase-kinase-14)