Identity
HGNC
LOCATION
17q23.3
LOCUSID
ALIAS
MAPKKK3,MEKK3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4215
MIM: 602539
HGNC: 6855
Ensembl: ENSG00000198909
Variants:
dbSNP: 4215
ClinVar: 4215
TCGA: ENSG00000198909
COSMIC: MAP3K3
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37658401 | 2023 | Somatic mutation spectrum of a Chinese cohort of pediatrics with vascular malformations. | 0 |
| 37658401 | 2023 | Somatic mutation spectrum of a Chinese cohort of pediatrics with vascular malformations. | 0 |
| 33729480 | 2021 | Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations. | 34 |
| 33812250 | 2021 | MEKK3 activates IRF7 to trigger a potent type I interferon induction in response to TLR7/9 signaling. | 3 |
| 33891857 | 2021 | Somatic MAP3K3 mutation defines a subclass of cerebral cavernous malformation. | 33 |
| 34189997 | 2021 | Circ_0006988 promotes the proliferation, metastasis and angiogenesis of non-small cell lung cancer cells by modulating miR-491-5p/MAP3K3 axis. | 11 |
| 33729480 | 2021 | Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations. | 34 |
| 33812250 | 2021 | MEKK3 activates IRF7 to trigger a potent type I interferon induction in response to TLR7/9 signaling. | 3 |
| 33891857 | 2021 | Somatic MAP3K3 mutation defines a subclass of cerebral cavernous malformation. | 33 |
| 34189997 | 2021 | Circ_0006988 promotes the proliferation, metastasis and angiogenesis of non-small cell lung cancer cells by modulating miR-491-5p/MAP3K3 axis. | 11 |
| 30628663 | 2019 | miR‑505 inhibits cell growth and EMT by targeting MAP3K3 through the AKT‑NFκB pathway in NSCLC cells. | 14 |
| 30652073 | 2019 | MiR-194 regulates nasopharyngeal carcinoma progression by modulating MAP3K3 expression. | 12 |
| 30896820 | 2019 | MicroRNA‑9 suppresses human prostate cancer cell viability, invasion and migration via modulation of mitogen‑activated protein kinase kinase kinase 3 expression. | 2 |
| 31182739 | 2019 | Overexpression of MAP3K3 promotes tumour growth through activation of the NF-κB signalling pathway in ovarian carcinoma. | 10 |
| 30628663 | 2019 | miR‑505 inhibits cell growth and EMT by targeting MAP3K3 through the AKT‑NFκB pathway in NSCLC cells. | 14 |
Citation
Dessen P
MAP3K3 (mitogen-activated protein kinase kinase kinase 3)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41280/map3k3-(mitogen-activated-protein-kinase-kinase-kinase-3)
