MAP3K4 (mitogen-activated protein kinase kinase kinase 4)

2003-11-01  

Identity

HGNC
LOCATION
6q26
LOCUSID
ALIAS
MAPKKK4,MEKK
FUSION GENES

Other Information

Locus ID:

NCBI: 4216
MIM: 602425
HGNC: 6856
Ensembl: ENSG00000085511

Variants:

dbSNP: 4216
ClinVar: 4216
TCGA: ENSG00000085511
COSMIC: MAP3K4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000085511ENST00000348824J3KNB8
ENSG00000085511ENST00000366919Q9Y6R4
ENSG00000085511ENST00000366920F5H538
ENSG00000085511ENST00000392142Q9Y6R4
ENSG00000085511ENST00000448119F5H534
ENSG00000085511ENST00000490904F5H1X6
ENSG00000085511ENST00000542952F5H2S6
ENSG00000085511ENST00000544041F5H4R1

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
GnRH signaling pathwayKEGGko04912
MAPK signaling pathwayKEGGhsa04010
GnRH signaling pathwayKEGGhsa04912
MAPK (JNK) signalingKEGGhsa_M00688
MAPK (p38) signalingKEGGhsa_M00689
MAPK (JNK) signalingKEGGM00688
MAPK (p38) signalingKEGGM00689

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381520552024CircMAP3K4 Suppresses H2O2-Induced Human Lens Epithelial Cell Injury by miR-630/ERCC6 Axis in Age-Related Cataract.0
381520552024CircMAP3K4 Suppresses H2O2-Induced Human Lens Epithelial Cell Injury by miR-630/ERCC6 Axis in Age-Related Cataract.0
360716822023CircMAP3K4 protects human lens epithelial cells from H(2)O(2)-induced dysfunction by targeting miR-193a-3p/PLCD3 axis in age-related cataract.0
360716822023CircMAP3K4 protects human lens epithelial cells from H(2)O(2)-induced dysfunction by targeting miR-193a-3p/PLCD3 axis in age-related cataract.0
354459592022Association between MAP3K4 gene polymorphisms and the risk of schizophrenia susceptibility in a Northeast Chinese Han population.0
363769502022Identification of MAP3K4 as a novel regulation factor of hepatic lipid metabolism in non-alcoholic fatty liver disease.3
354459592022Association between MAP3K4 gene polymorphisms and the risk of schizophrenia susceptibility in a Northeast Chinese Han population.0
363769502022Identification of MAP3K4 as a novel regulation factor of hepatic lipid metabolism in non-alcoholic fatty liver disease.3
319152442020A genome-wide analysis of targets of macrolide antibiotics in mammalian cells.6
328599432020Coordinated regulation of Rel expression by MAP3K4, CBP, and HDAC6 controls phenotypic switching.3
319152442020A genome-wide analysis of targets of macrolide antibiotics in mammalian cells.6
328599432020Coordinated regulation of Rel expression by MAP3K4, CBP, and HDAC6 controls phenotypic switching.3
306085802019Mutations in MAP3K1 that cause 46,XY disorders of sex development disrupt distinct structural domains in the protein.13
306085802019Mutations in MAP3K1 that cause 46,XY disorders of sex development disrupt distinct structural domains in the protein.13
302174502018Activation of JNK signaling in osteoblasts is inversely correlated with collagen synthesis in age-related osteoporosis.13

Citation

Dessen P

MAP3K4 (mitogen-activated protein kinase kinase kinase 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41281/map3k4-(mitogen-activated-protein-kinase-kinase-kinase-4)