Identity
HGNC
LOCATION
6q23.3
LOCUSID
ALIAS
ASK1,MAPKKK5,MEKK5
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4217
MIM: 602448
HGNC: 6857
Ensembl: ENSG00000197442
Variants:
dbSNP: 4217
ClinVar: 4217
TCGA: ENSG00000197442
COSMIC: MAP3K5
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000197442 | ENST00000359015 | Q99683 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA445833 | Thalassemia | Disease | ClinicalAnnotation | associated | PD | 23556445 | |
| PA449942 | hydroxyurea | Chemical | ClinicalAnnotation | associated | PD | 23556445 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36951032 | 2024 | Multiple Pathway-Dephosphorylated ASK-1 Confers Temozolomide-Resistance to Human Glioma Cells. | 0 |
| 36951032 | 2024 | Multiple Pathway-Dephosphorylated ASK-1 Confers Temozolomide-Resistance to Human Glioma Cells. | 0 |
| 37340918 | 2023 | [Tumor antigen-loaded dendritic cells combined with cytokine-induced killer (CIK) enhance the killing activity of human esophageal cancer cells by promoting ASK1 activation]. | 0 |
| 37340918 | 2023 | [Tumor antigen-loaded dendritic cells combined with cytokine-induced killer (CIK) enhance the killing activity of human esophageal cancer cells by promoting ASK1 activation]. | 0 |
| 34850317 | 2022 | Clinical investigation of lipopolysaccharide in the persistence of metabolic syndrome (MS) through the activation of GRP78-IRE1α-ASK1 signaling pathway. | 0 |
| 35438255 | 2022 | Phosphoproteomics identifies pathways underlying the role of receptor-interaction protein kinase 3 in alcohol-associated liver disease and uncovers apoptosis signal-regulating kinase 1 as a target. | 7 |
| 35689994 | 2022 | Catalytic activity in vitro of the human protein kinase ASK1 mutants: Experimental and molecular simulation study. | 1 |
| 35798237 | 2022 | Apoptosis signal-regulating kinase-1 regulates thrombin-induced endothelial permeability. | 2 |
| 36189587 | 2022 | Oxidative Stress Kinase Activation and Impaired Insulin Receptor Signaling Precede Overt Alzheimer's Disease Neuropathology. | 0 |
| 34850317 | 2022 | Clinical investigation of lipopolysaccharide in the persistence of metabolic syndrome (MS) through the activation of GRP78-IRE1α-ASK1 signaling pathway. | 0 |
| 35438255 | 2022 | Phosphoproteomics identifies pathways underlying the role of receptor-interaction protein kinase 3 in alcohol-associated liver disease and uncovers apoptosis signal-regulating kinase 1 as a target. | 7 |
| 35689994 | 2022 | Catalytic activity in vitro of the human protein kinase ASK1 mutants: Experimental and molecular simulation study. | 1 |
| 35798237 | 2022 | Apoptosis signal-regulating kinase-1 regulates thrombin-induced endothelial permeability. | 2 |
| 36189587 | 2022 | Oxidative Stress Kinase Activation and Impaired Insulin Receptor Signaling Precede Overt Alzheimer's Disease Neuropathology. | 0 |
| 32876895 | 2021 | MicroRNA-532-3p Regulates Pro-Inflammatory Human THP-1 Macrophages by Targeting ASK1/p38 MAPK Pathway. | 6 |
Citation
Dessen P
MAP3K5 (mitogen-activated protein kinase kinase kinase 5)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/41282
