Identity
HGNC
LOCATION
10p11.23
LOCUSID
ALIAS
AURA2,COT,EST,ESTF,MEKK8,TPL2,Tpl-2,c-COT
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1326
MIM: 191195
HGNC: 6860
Ensembl: ENSG00000107968
Variants:
dbSNP: 1326
ClinVar: 1326
TCGA: ENSG00000107968
COSMIC: MAP3K8
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38233731 | 2024 | Clinical, Morphologic, and Molecular Features of MAP3K8 Rearranged Spitz Neoplasms: A Retrospective Study Documenting That Bonafide Spitz Melanomas Are Rare. | 0 |
| 38233731 | 2024 | Clinical, Morphologic, and Molecular Features of MAP3K8 Rearranged Spitz Neoplasms: A Retrospective Study Documenting That Bonafide Spitz Melanomas Are Rare. | 0 |
| 36764206 | 2023 | Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease. | 0 |
| 36768307 | 2023 | Epigenetic Regulation of MAP3K8 in EBV-Associated Gastric Carcinoma. | 4 |
| 37833434 | 2023 | Overexpression of TPL2 may be a predictor of good prognosis in patients with breast invasive ductal carcinoma. | 0 |
| 36764206 | 2023 | Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease. | 0 |
| 36768307 | 2023 | Epigenetic Regulation of MAP3K8 in EBV-Associated Gastric Carcinoma. | 4 |
| 37833434 | 2023 | Overexpression of TPL2 may be a predictor of good prognosis in patients with breast invasive ductal carcinoma. | 0 |
| 35218437 | 2022 | Cell adhesion tunes inflammatory TPL2 kinase signal transduction. | 0 |
| 35325006 | 2022 | Loss of Tpl2 activates compensatory signaling and resistance to EGFR/MET dual inhibition in v-RAS transduced keratinocytes. | 0 |
| 35982895 | 2022 | ALKBH5/MAP3K8 axis regulates PD-L1+ macrophage infiltration and promotes hepatocellular carcinoma progression. | 25 |
| 35218437 | 2022 | Cell adhesion tunes inflammatory TPL2 kinase signal transduction. | 0 |
| 35325006 | 2022 | Loss of Tpl2 activates compensatory signaling and resistance to EGFR/MET dual inhibition in v-RAS transduced keratinocytes. | 0 |
| 35982895 | 2022 | ALKBH5/MAP3K8 axis regulates PD-L1+ macrophage infiltration and promotes hepatocellular carcinoma progression. | 25 |
| 33443087 | 2021 | MAP3K8 Regulates Cox-2-Mediated Prostaglandin E(2) Production in the Lung and Suppresses Pulmonary Inflammation and Fibrosis. | 11 |
Citation
Dessen P
MAP3K8 (mitogen-activated protein kinase kinase kinase 8)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41284
