Identity
HGNC
LOCATION
14q24.2
LOCUSID
ALIAS
MEKK9,MLK1,PRKE1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4293
MIM: 600136
HGNC: 6861
Ensembl: ENSG00000006432
Variants:
dbSNP: 4293
ClinVar: 4293
TCGA: ENSG00000006432
COSMIC: MAP3K9
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| MAPK (JNK) signaling | KEGG | hsa_M00688 |
| MAPK (p38) signaling | KEGG | hsa_M00689 |
| MAPK (JNK) signaling | KEGG | M00688 |
| MAPK (p38) signaling | KEGG | M00689 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35188403 | 2022 | Elevation of miR-125b-5p is related to improved prognosis in laryngeal squamous cell carcinoma and inhibits the malignancy and glycometabolic disorder by targeting MAP3K9. | 1 |
| 35388129 | 2022 | Promoter methylation-regulated miR-148a-3p inhibits lung adenocarcinoma (LUAD) progression by targeting MAP3K9. | 10 |
| 35978511 | 2022 | CircSPI1_005 ameliorates osteoarthritis by sponging miR-370-3p to regulate the expression of MAP3K9. | 2 |
| 35188403 | 2022 | Elevation of miR-125b-5p is related to improved prognosis in laryngeal squamous cell carcinoma and inhibits the malignancy and glycometabolic disorder by targeting MAP3K9. | 1 |
| 35388129 | 2022 | Promoter methylation-regulated miR-148a-3p inhibits lung adenocarcinoma (LUAD) progression by targeting MAP3K9. | 10 |
| 35978511 | 2022 | CircSPI1_005 ameliorates osteoarthritis by sponging miR-370-3p to regulate the expression of MAP3K9. | 2 |
| 31115491 | 2019 | miR‑490‑5p regulates the proliferation, migration, invasion and epithelial‑mesenchymal transition of pharyngolaryngeal cancer cells by targeting mitogen‑activated protein kinase kinasekinase 9. | 8 |
| 31378889 | 2019 | MicroRNA-148a regulates the MAPK/ERK signaling pathway and suppresses the development of esophagus squamous cell carcinoma via targeting MAP3K9. | 9 |
| 31115491 | 2019 | miR‑490‑5p regulates the proliferation, migration, invasion and epithelial‑mesenchymal transition of pharyngolaryngeal cancer cells by targeting mitogen‑activated protein kinase kinasekinase 9. | 8 |
| 31378889 | 2019 | MicroRNA-148a regulates the MAPK/ERK signaling pathway and suppresses the development of esophagus squamous cell carcinoma via targeting MAP3K9. | 9 |
| 28081468 | 2017 | Role of miR-15a in intervertebral disc degeneration through targeting MAP3K9. | 25 |
| 28298643 | 2017 | MKL1 defines the H3K4Me3 landscape for NF-κB dependent inflammatory response. | 30 |
| 28081468 | 2017 | Role of miR-15a in intervertebral disc degeneration through targeting MAP3K9. | 25 |
| 28298643 | 2017 | MKL1 defines the H3K4Me3 landscape for NF-κB dependent inflammatory response. | 30 |
| 26573018 | 2016 | MicroRNA-148b enhances proliferation and apoptosis in human renal cancer cells via directly targeting MAP3K9. | 12 |
Citation
Dessen P
MAP3K9 (mitogen-activated protein kinase kinase kinase 9)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41285/map3k9-(mitogen-activated-protein-kinase-kinase-kinase-9)
