MAPKAPK5 (MAPK activated protein kinase 5)

2003-11-01 Affiliation

Identity

HGNC

MAPKAPK5

LOCATION

12q24.12

LOCUSID

8550

ALIAS

MAPKAP-K5,MK-5,MK5,PRAK

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8550
MIM: 606723
HGNC: 6889
Ensembl: ENSG00000089022

Variants:

dbSNP: 8550
ClinVar: 8550
TCGA: ENSG00000089022
COSMIC: MAPKAPK5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000089022	ENST00000547305	R4GN93
ENSG00000089022	ENST00000549875	R4GN33
ENSG00000089022	ENST00000550735	Q8IW41
ENSG00000089022	ENST00000551404	Q8IW41
ENSG00000089022	ENST00000553053	F8VRP2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
MAPK signaling pathway	KEGG	hsa04010
Signal Transduction	REACTOME	R-HSA-162582
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK6/MAPK4 signaling	REACTOME	R-HSA-5687128
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular Senescence	REACTOME	R-HSA-2559583
Oxidative Stress Induced Senescence	REACTOME	R-HSA-2559580
Regulation of TP53 Activity	REACTOME	R-HSA-5633007
Regulation of TP53 Activity through Phosphorylation	REACTOME	R-HSA-6804756

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
21336308	2011	Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1.	63
22279049	2012	IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling.	44
19166925	2009	PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5.	32
21177870	2011	Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.	26
19473979	2009	Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif.	19
23685072	2013	A posttranslational modification cascade involving p38, Tip60, and PRAK mediates oncogene-induced senescence.	15
26080319	2015	Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes.	14
19484198	2009	The transcriptional regulation and cell-specific expression of the MAPK-activated protein kinase MK5.	12
26758977	2016	The novel RAGE interactor PRAK is associated with autophagy signaling in Alzheimer's disease pathogenesis.	7
20849292	2011	Cross-talk between protein kinase A and the MAPK-activated protein kinases RSK1 and MK5.	6

Citation

Dessen P

MAPKAPK5 (MAPK activated protein kinase 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41296/mapkapk5-(mapk-activated-protein-kinase-5)