MAPT (microtubule associated protein tau)

2003-11-01  

Identity

HGNC
MAPT
LOCATION
17q21.31
LOCUSID
4137
ALIAS
DDPAC,FTDP-17,MAPTL,MSTD,MTBT1,MTBT2,PPND,PPP1R103,TAU,tau-40
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4137
MIM: 157140
HGNC: 6893
Ensembl: ENSG00000186868

Variants:

dbSNP: 4137
ClinVar: 4137
TCGA: ENSG00000186868
COSMIC: MAPT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186868ENST00000262410P10636
ENSG00000186868ENST00000262410A0A024R9Y1
ENSG00000186868ENST00000334239P10636
ENSG00000186868ENST00000340799P10636
ENSG00000186868ENST00000344290P10636
ENSG00000186868ENST00000351559P10636
ENSG00000186868ENST00000351559A0A024RA17
ENSG00000186868ENST00000415613P10636
ENSG00000186868ENST00000420682P10636
ENSG00000186868ENST00000431008P10636
ENSG00000186868ENST00000446361P10636
ENSG00000186868ENST00000446361A0A024R9Y0
ENSG00000186868ENST00000535772P10636
ENSG00000186868ENST00000571311I3L2Z2
ENSG00000186868ENST00000571987P10636
ENSG00000186868ENST00000571987A0A024R9Y1
ENSG00000186868ENST00000574436P10636
ENSG00000186868ENST00000574436A0A024RA17

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Alzheimer's diseaseKEGGko05010
MAPK signaling pathwayKEGGhsa04010
Alzheimer's diseaseKEGGhsa05010
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptotic cleavage of cellular proteinsREACTOMER-HSA-111465
Caspase-mediated cleavage of cytoskeletal proteinsREACTOMER-HSA-264870

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
372646102024Tau in dementia with Lewy bodies.1
375308942024Associations of plasma NfL, GFAP, and t-tau with cerebral small vessel disease and incident dementia: longitudinal data of the AGES-Reykjavik Study.2
375778522024The relationship between APOE genotype, CSF Tau and cognition across the Alzheimer's disease spectrum, moderation and mediation role of insula network connectivity.1
376334692024Abnormal interaction of Rlip with mutant APP/Abeta and phosphorylated tau reduces wild-type Rlip levels and disrupt Rlip function in Alzheimer's disease.0
376394922024Plasma phosphorylated tau-217 exhibits sex-specific prognostication of cognitive decline and brain atrophy in cognitively unimpaired adults.4
376419132024Activation of transient receptor potential vanilloid 1 ameliorates tau accumulation-induced synaptic damage and cognitive dysfunction via autophagy enhancement.2
377033112024Glial reactivity and T cell infiltration in frontotemporal lobar degeneration with tau pathology.1
377255892024Temporal Profiles of P-Tau, T-Tau, and P-Tau:Tau Ratios in Cerebrospinal Fluid and Blood from Moderate-Severe Traumatic Brain Injury Patients and Relationship to 6-12 Month Global Outcomes.2
378207512024Apathy-like behaviour in tau mouse models of Alzheimer's disease and frontotemporal dementia.0
378373822024Combined Connectomics, MAPT Gene Expression, and Amyloid Deposition to Explain Regional Tau Deposition in Alzheimer Disease.1
379558062024DLK-MAPK Signaling Coupled with DNA Damage Promotes Intrinsic Neurotoxicity Associated with Non-Mutated Tau.3
379881692024Galectin-3 aggravates microglial activation and tau transmission in tauopathy.1
380730602024Tau and neurodegeneration.4
380863892024APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread.9
381233622024Spatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging.0

Citation

Dessen P

MAPT (microtubule associated protein tau)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41299/mapt-(microtubule-associated-protein-tau)