Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1991
MIM: 130130
HGNC: 3309
Ensembl: ENSG00000197561
Variants:
dbSNP: 1991
ClinVar: 1991
TCGA: ENSG00000197561
COSMIC: ELANE
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000197561 | ENST00000263621 | P08246 |
| ENSG00000197561 | ENST00000590230 | P08246 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37796181 | 2024 | Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis. | 1 |
| 38042488 | 2024 | Position-specific N- and O-glycosylation of the reactive center loop impacts neutrophil elastase-mediated proteolysis of corticosteroid-binding globulin. | 1 |
| 38167145 | 2024 | Elevated first-trimester neutrophil elastase and proteinase 3 increase the risk of gestational diabetes mellitus and adverse fetal outcomes. | 1 |
| 38226800 | 2024 | ELANE rs17223045C/T and rs3761007G/A variants: Protective factors against COVID-19. | 0 |
| 38673851 | 2024 | Neutrophil Elastase Degrades Histone Deacetylases and Sirtuin 1 in Primary Human Monocyte Derived Macrophages. | 0 |
| 37796181 | 2024 | Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis. | 1 |
| 38042488 | 2024 | Position-specific N- and O-glycosylation of the reactive center loop impacts neutrophil elastase-mediated proteolysis of corticosteroid-binding globulin. | 1 |
| 38167145 | 2024 | Elevated first-trimester neutrophil elastase and proteinase 3 increase the risk of gestational diabetes mellitus and adverse fetal outcomes. | 1 |
| 38226800 | 2024 | ELANE rs17223045C/T and rs3761007G/A variants: Protective factors against COVID-19. | 0 |
| 38673851 | 2024 | Neutrophil Elastase Degrades Histone Deacetylases and Sirtuin 1 in Primary Human Monocyte Derived Macrophages. | 0 |
| 37047578 | 2023 | The Direct Anti-Virulence but Not Bactericidal Activity of Human Neutrophil Elastase against Moraxella catarrhalis. | 0 |
| 37118811 | 2023 | Paediatric autoimmune diseases with ELANE mutations associated with neutropenia. | 0 |
| 37187291 | 2023 | Neutrophil elastase decreases SARS-CoV-2 spike protein binding to human bronchial epithelia by clipping ACE-2 ectodomain from the epithelial surface. | 3 |
| 37686340 | 2023 | Could the Oxidation of α1-Antitrypsin Prevent the Binding of Human Neutrophil Elastase in COVID-19 Patients? | 0 |
| 37047578 | 2023 | The Direct Anti-Virulence but Not Bactericidal Activity of Human Neutrophil Elastase against Moraxella catarrhalis. | 0 |
Citation
Dessen P
ELANE (elastase, neutrophil expressed)
Atlas Genet Cytogenet Oncol Haematol. 2009-05-01
Online version: http://atlasgeneticsoncology.org/gene/413
