MARK2 (microtubule affinity regulating kinase 2)

2003-06-01  

Identity

HGNC
MARK2
LOCATION
11q13.1
LOCUSID
2011
ALIAS
EMK-1,EMK1,PAR-1,Par-1b,Par1b
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2011
MIM: 600526
HGNC: 3332
Ensembl: ENSG00000072518

Variants:

dbSNP: 2011
ClinVar: 2011
TCGA: ENSG00000072518
COSMIC: MARK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072518ENST00000350490Q7KZI7
ENSG00000072518ENST00000361128Q7KZI7
ENSG00000072518ENST00000361128A0A140VJP1
ENSG00000072518ENST00000377810E7ETY4
ENSG00000072518ENST00000402010Q7KZI7
ENSG00000072518ENST00000408948Q7KZI7
ENSG00000072518ENST00000408948A0A024R5B2
ENSG00000072518ENST00000425897E7ETY4
ENSG00000072518ENST00000502399E9PC69
ENSG00000072518ENST00000508192Q7KZI7
ENSG00000072518ENST00000509502Q7KZI7
ENSG00000072518ENST00000512060A0A1B0GXH6
ENSG00000072518ENST00000513765Q7KZI7
ENSG00000072518ENST00000540169F5H6N2
ENSG00000072518ENST00000543220F5H4F6
ENSG00000072518ENST00000543674F5H4J8

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387099232024MARK2 phosphorylates KIF13A at a 14-3-3 binding site to polarize vesicular transport of transferrin receptor within dendrites.0
387099232024MARK2 phosphorylates KIF13A at a 14-3-3 binding site to polarize vesicular transport of transferrin receptor within dendrites.0
347937752022Long non-coding RNA ABHD11-AS1 facilitates the progression of cervical cancer by competitively binding to miR-330-5p and upregulating MARK2.4
350484052022MARK2 potentiate aerobic glycolysis-mediated cell growth in breast cancer through regulating mTOR/HIF-1α and p53 pathways.4
351928922022MARK2/4 promotes Warburg effect and cell growth in non-small cell lung carcinoma through the AMPKα1/mTOR/HIF-1α signaling pathway.6
354699202022Identification of a reciprocal negative feedback loop between tau-modifying proteins MARK2 kinase and CBP acetyltransferase.0
347937752022Long non-coding RNA ABHD11-AS1 facilitates the progression of cervical cancer by competitively binding to miR-330-5p and upregulating MARK2.4
350484052022MARK2 potentiate aerobic glycolysis-mediated cell growth in breast cancer through regulating mTOR/HIF-1α and p53 pathways.4
351928922022MARK2/4 promotes Warburg effect and cell growth in non-small cell lung carcinoma through the AMPKα1/mTOR/HIF-1α signaling pathway.6
354699202022Identification of a reciprocal negative feedback loop between tau-modifying proteins MARK2 kinase and CBP acetyltransferase.0
335960872021The cell polarity kinase Par1b/MARK2 activation selects specific NF-kB transcripts via phosphorylation of core mediator Med17/TRAP80.2
337053882021MARK2 phosphorylates eIF2α in response to proteotoxic stress.16
335960872021The cell polarity kinase Par1b/MARK2 activation selects specific NF-kB transcripts via phosphorylation of core mediator Med17/TRAP80.2
337053882021MARK2 phosphorylates eIF2α in response to proteotoxic stress.16
305806662019Inhibition of polarity-regulating kinase PAR1b contributes to Helicobacter pylori inflicted DNA Double Strand Breaks in gastric cells.8

Citation

Dessen P

MARK2 (microtubule affinity regulating kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41300/mark2-(microtubule-affinity-regulating-kinase-2)