MBD1 (methyl-CpG binding domain protein 1)

2003-02-01  

Identity

HGNC
MBD1
LOCATION
18q21.1
LOCUSID
4152
ALIAS
CXXC3,PCM1,RFT
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4152
MIM: 156535
HGNC: 6916
Ensembl: ENSG00000141644

Variants:

dbSNP: 4152
ClinVar: 4152
TCGA: ENSG00000141644
COSMIC: MBD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141644ENST00000269468Q9UIS9
ENSG00000141644ENST00000269471Q9UIS9
ENSG00000141644ENST00000339998Q9UIS9
ENSG00000141644ENST00000347968Q9UIS9
ENSG00000141644ENST00000353909Q9UIS9
ENSG00000141644ENST00000382948Q9UIS9
ENSG00000141644ENST00000398488Q9UIS9
ENSG00000141644ENST00000398493Q9UIS9
ENSG00000141644ENST00000398495A0A0A0MS90
ENSG00000141644ENST00000457839Q9UIS9
ENSG00000141644ENST00000585595Q9UIS9
ENSG00000141644ENST00000585672Q9UIS9
ENSG00000141644ENST00000587605Q9UIS9
ENSG00000141644ENST00000588937Q9UIS9
ENSG00000141644ENST00000589541K7EN65
ENSG00000141644ENST00000589733K7EMA9
ENSG00000141644ENST00000590208Q9UIS9
ENSG00000141644ENST00000590215K7EIN3
ENSG00000141644ENST00000591416Q9UIS9
ENSG00000141644ENST00000591535Q9UIS9
ENSG00000141644ENST00000592060K7EPZ6

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
304876992018Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer.11
304876992018Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer.11
277445832017Disease-causing point-mutations in metal-binding domains of Wilson disease protein decrease stability and increase structural dynamics.4
283773002017CpG dinucleotide positioning patterns determine the binding affinity of methyl-binding domain to nucleosomes.1
284490872017Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner.19
284739812017Screening of Tumor Suppressor Genes in Metastatic Colorectal Cancer.9
277445832017Disease-causing point-mutations in metal-binding domains of Wilson disease protein decrease stability and increase structural dynamics.4
283773002017CpG dinucleotide positioning patterns determine the binding affinity of methyl-binding domain to nucleosomes.1
284490872017Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner.19
284739812017Screening of Tumor Suppressor Genes in Metastatic Colorectal Cancer.9
269806962016MBD1 is an Epigenetic Regulator of KEAP1 in Pancreatic Cancer.11
269806962016MBD1 is an Epigenetic Regulator of KEAP1 in Pancreatic Cancer.11
256580352015Molecular dynamics study of the recognition of dimethylated CpG sites by MBD1 protein.5
257985782015SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation.55
256580352015Molecular dynamics study of the recognition of dimethylated CpG sites by MBD1 protein.5

Citation

Dessen P

MBD1 (methyl-CpG binding domain protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41308/mbd1-(methyl-cpg-binding-domain-protein-1)