MBD3 (methyl-CpG binding domain protein 3)

2003-06-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 53615
MIM: 603573
HGNC: 6918
Ensembl: ENSG00000071655

Variants:

dbSNP: 53615
ClinVar: 53615
TCGA: ENSG00000071655
COSMIC: MBD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000071655ENST00000434436O95983
ENSG00000071655ENST00000585903A0A087WVG6
ENSG00000071655ENST00000585967A0A087X1H1
ENSG00000071655ENST00000590550K7EIE8
ENSG00000071655ENST00000592012A0A0A0MTS6
ENSG00000071655ENST00000592361A0A087WT34
ENSG00000071655ENST00000592965A0A087WZ12

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase I TranscriptionREACTOMER-HSA-73864
RNA Polymerase I Promoter ClearanceREACTOMER-HSA-73854
RNA Polymerase I Transcription InitiationREACTOMER-HSA-73762
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDACs deacetylate histonesREACTOMER-HSA-3214815
Positive epigenetic regulation of rRNA expressionREACTOMER-HSA-5250913
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through AcetylationREACTOMER-HSA-6804758
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionREACTOMER-HSA-427389

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
164284402006MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.147
243859262013MBD3 localizes at promoters, gene bodies and enhancers of active genes.50
233614642013Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and binding to exon sequences.47
186448632008MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks.42
121834692002Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3.35
123547582002MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase.19
174524522007Epigenetic programming of the rRNA promoter by MBD3.17
257536722015Dissecting the behavior and function of MBD3 in DNA methylation homeostasis by single-molecule spectroscopy and microscopy.16
157016002005MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.14
186027682008DNA demethylation induced by the methyl-CpG-binding domain protein MBD3.12

Citation

Dessen P

MBD3 (methyl-CpG binding domain protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41310/mbd3-(methyl-cpg-binding-domain-protein-3)