MCF2 (MCF.2 cell line derived transforming sequence)

2003-02-01 Affiliation

Identity

HGNC

MCF2

LOCATION

Xq27.1

LOCUSID

4168

ALIAS

ARHGEF21,DBL

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4168
MIM: 311030
HGNC: 6940
Ensembl: ENSG00000101977

Variants:

dbSNP: 4168
ClinVar: 4168
TCGA: ENSG00000101977
COSMIC: MCF2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000101977	ENST00000338585	P10911
ENSG00000101977	ENST00000370573	P10911
ENSG00000101977	ENST00000370576	P10911
ENSG00000101977	ENST00000414978	P10911
ENSG00000101977	ENST00000437564	H0Y662
ENSG00000101977	ENST00000446225	Q5JYJ5
ENSG00000101977	ENST00000519895	P10911
ENSG00000101977	ENST00000520602	A0A2U3TZL4
ENSG00000101977	ENST00000536274	P10911

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signalling by NGF	REACTOME	R-HSA-166520
p75 NTR receptor-mediated signalling	REACTOME	R-HSA-193704
Cell death signalling via NRAGE, NRIF and NADE	REACTOME	R-HSA-204998
NRAGE signals death through JNK	REACTOME	R-HSA-193648
Signaling by Rho GTPases	REACTOME	R-HSA-194315
Rho GTPase cycle	REACTOME	R-HSA-194840
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (12/13) signalling events	REACTOME	R-HSA-416482

References

Pubmed ID	Year	Title	Citations
31416844	2019	Src-Dependent DBL Family Members Drive Resistance to Vemurafenib in Human Melanoma.	13
31416844	2019	Src-Dependent DBL Family Members Drive Resistance to Vemurafenib in Human Melanoma.	13
25723869	2015	Dbl oncogene expression in MCF-10 A epithelial cells disrupts mammary acinar architecture, induces EMT and angiogenic factor secretion.	2
25723869	2015	Dbl oncogene expression in MCF-10 A epithelial cells disrupts mammary acinar architecture, induces EMT and angiogenic factor secretion.	2
22984590	2012	Phosphoinositide 3-kinase C2β regulates RhoA and the actin cytoskeleton through an interaction with Dbl.	7
22984590	2012	Phosphoinositide 3-kinase C2β regulates RhoA and the actin cytoskeleton through an interaction with Dbl.	7
20479760	2011	Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia.	148
21712385	2011	The tumor suppressor hamartin enhances Dbl protein transforming activity through interaction with ezrin.	7
20479760	2011	Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia.	148
21712385	2011	The tumor suppressor hamartin enhances Dbl protein transforming activity through interaction with ezrin.	7
19373475	2009	Mutational analysis of proto-oncogene Dbl on Xq27 in testicular germ cell tumors reveals a rare SNP in a patient with bilateral undescended testis.	2
19373475	2009	Mutational analysis of proto-oncogene Dbl on Xq27 in testicular germ cell tumors reveals a rare SNP in a patient with bilateral undescended testis.	2
18728402	2008	The suppressor of metastasis Nm23-H1 interacts with the Cdc42 Rho family member and the pleckstrin homology domain of oncoprotein Dbl-1 to suppress cell migration.	23
18728402	2008	The suppressor of metastasis Nm23-H1 interacts with the Cdc42 Rho family member and the pleckstrin homology domain of oncoprotein Dbl-1 to suppress cell migration.	23
17538024	2007	Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42.	49

Citation

Dessen P

MCF2 (MCF.2 cell line derived transforming sequence)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41315/mcf2-(mcf-2-cell-line-derived-transforming-sequence)