MCM2 (minichromosome maintenance complex component 2)

2003-02-01  

Identity

HGNC
MCM2
LOCATION
3q21.3
LOCUSID
4171
ALIAS
BM28,CCNL1,CDCL1,D3S3194,DFNA70,MITOTIN,cdc19
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4171
MIM: 116945
HGNC: 6944
Ensembl: ENSG00000073111

Variants:

dbSNP: 4171
ClinVar: 4171
TCGA: ENSG00000073111
COSMIC: MCM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000073111ENST00000265056P49736
ENSG00000073111ENST00000472731C9J013
ENSG00000073111ENST00000474964F8WDM3
ENSG00000073111ENST00000477668H7C4N9
ENSG00000073111ENST00000480910C9JZ21
ENSG00000073111ENST00000491422H0Y8E6

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DNA replicationKEGGko03030
Cell cycleKEGGko04110
DNA replicationKEGGhsa03030
Cell cycleKEGGhsa04110
MCM complexKEGGhsa_M00285
MCM complexKEGGM00285
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
Activation of ATR in response to replication stressREACTOMER-HSA-176187
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
Activation of the pre-replicative complexREACTOMER-HSA-68962
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
Switching of origins to a post-replicative stateREACTOMER-HSA-69052
Orc1 removal from chromatinREACTOMER-HSA-68949
DNA strand elongationREACTOMER-HSA-69190
Unwinding of DNAREACTOMER-HSA-176974
Regulation of DNA replicationREACTOMER-HSA-69304
Removal of licensing factors from originsREACTOMER-HSA-69300
M/G1 TransitionREACTOMER-HSA-68874
DNA Replication Pre-InitiationREACTOMER-HSA-69002
Assembly of the pre-replicative complexREACTOMER-HSA-68867
DNA ReplicationREACTOMER-HSA-69306

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384034592024MCM2 is involved in subtyping and tamoxifen resistance of ERα-positive breast cancer by acting as the downstream factor of ERα.0
384544432024Regulation of cancer stem cells by CXCL1, a chemokine whose secretion is controlled by MCM2.0
384034592024MCM2 is involved in subtyping and tamoxifen resistance of ERα-positive breast cancer by acting as the downstream factor of ERα.0
384544432024Regulation of cancer stem cells by CXCL1, a chemokine whose secretion is controlled by MCM2.0
367781102023ESRG is critical to maintain the cell survival and self-renewal/pluripotency of hPSCs by collaborating with MCM2 to suppress p53 pathway.2
368077392023The importance of nuclear RAGE-Mcm2 axis in diabetes or cancer-associated replication stress.1
373585512023Circ_0104700 contributes to acute myeloid leukemia progression by enhancing MCM2 expression through targeting miR-665.1
380533782023MCM2 promotes the stemness of endometrial cancer cells via the Akt/β-catenin pathway.0
367781102023ESRG is critical to maintain the cell survival and self-renewal/pluripotency of hPSCs by collaborating with MCM2 to suppress p53 pathway.2
368077392023The importance of nuclear RAGE-Mcm2 axis in diabetes or cancer-associated replication stress.1
373585512023Circ_0104700 contributes to acute myeloid leukemia progression by enhancing MCM2 expression through targeting miR-665.1
380533782023MCM2 promotes the stemness of endometrial cancer cells via the Akt/β-catenin pathway.0
350931192022Demethylation at enhancer upregulates MCM2 and NUP37 expression predicting poor survival in hepatocellular carcinoma patients.10
353076462022MCM2 promotes the proliferation, migration and invasion of cholangiocarcinoma cells by reducing the p53 signaling pathway.2
354386322022MCMBP promotes the assembly of the MCM2-7 hetero-hexamer to ensure robust DNA replication in human cells.13

Citation

Dessen P

MCM2 (minichromosome maintenance complex component 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41318/mcm2-(minichromosome-maintenance-complex-component-2)