MCM4 (minichromosome maintenance complex component 4)

2003-05-01  

Identity

HGNC
MCM4
LOCATION
8q11.21
LOCUSID
4173
ALIAS
CDC21,CDC54,IMD54,NKCD,NKGCD,P1-CDC21,hCdc21
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4173
MIM: 602638
HGNC: 6947
Ensembl: ENSG00000104738

Variants:

dbSNP: 4173
ClinVar: 4173
TCGA: ENSG00000104738
COSMIC: MCM4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104738ENST00000262105P33991
ENSG00000104738ENST00000518221E5RFR3
ENSG00000104738ENST00000518382E5RHP5
ENSG00000104738ENST00000520637E5RG31
ENSG00000104738ENST00000524086E5RG53
ENSG00000104738ENST00000647877A0A3B3ISC1
ENSG00000104738ENST00000648407A0A3B3ITP6
ENSG00000104738ENST00000648519A0A3B3IS88
ENSG00000104738ENST00000648554A0A3B3IRR8
ENSG00000104738ENST00000649838A0A3B3IT92
ENSG00000104738ENST00000649919A0A3B3IU45
ENSG00000104738ENST00000649973P33991
ENSG00000104738ENST00000650216A0A3B3IS57

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DNA replicationKEGGko03030
Cell cycleKEGGko04110
DNA replicationKEGGhsa03030
Cell cycleKEGGhsa04110
MCM complexKEGGhsa_M00285
MCM complexKEGGM00285
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
Activation of ATR in response to replication stressREACTOMER-HSA-176187
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
Activation of the pre-replicative complexREACTOMER-HSA-68962
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
Switching of origins to a post-replicative stateREACTOMER-HSA-69052
Orc1 removal from chromatinREACTOMER-HSA-68949
DNA strand elongationREACTOMER-HSA-69190
Unwinding of DNAREACTOMER-HSA-176974
Regulation of DNA replicationREACTOMER-HSA-69304
Removal of licensing factors from originsREACTOMER-HSA-69300
M/G1 TransitionREACTOMER-HSA-68874
DNA Replication Pre-InitiationREACTOMER-HSA-69002
Assembly of the pre-replicative complexREACTOMER-HSA-68867
DNA ReplicationREACTOMER-HSA-69306

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382160922024Identification of MCM4 and PRKDC as new regulators of osteosarcoma cell dormancy based on 3D cell cultures.1
382160922024Identification of MCM4 and PRKDC as new regulators of osteosarcoma cell dormancy based on 3D cell cultures.1
358308492023Minichromosome Maintenance 4 Is Associated with Cancer Stemness and Poor Survival of Patients with Gastric Cancer.2
358308492023Minichromosome Maintenance 4 Is Associated with Cancer Stemness and Poor Survival of Patients with Gastric Cancer.2
337162562021MCM4 in human hepatocellular carcinoma: a potent prognostic factor associated with cell proliferation.7
349618412021Identification of MCM4 as a Prognostic Marker of Hepatocellular Carcinoma.9
337162562021MCM4 in human hepatocellular carcinoma: a potent prognostic factor associated with cell proliferation.7
349618412021Identification of MCM4 as a Prognostic Marker of Hepatocellular Carcinoma.9
313230402019Genome-wide investigation of the clinical significance and prospective molecular mechanism of minichromosome maintenance protein family genes in patients with Lung Adenocarcinoma.11
314765942019MCM2, MCM4, and MCM6 in Breast Cancer: Clinical Utility in Diagnosis and Prognosis.57
315455012019Prognostic significance of minichromosome maintenance mRNA expression in human lung adenocarcinoma.11
313230402019Genome-wide investigation of the clinical significance and prospective molecular mechanism of minichromosome maintenance protein family genes in patients with Lung Adenocarcinoma.11
314765942019MCM2, MCM4, and MCM6 in Breast Cancer: Clinical Utility in Diagnosis and Prognosis.57
315455012019Prognostic significance of minichromosome maintenance mRNA expression in human lung adenocarcinoma.11
301841072018Function of the amino-terminal region of human MCM4 in helicase activity.4

Citation

Dessen P

MCM4 (minichromosome maintenance complex component 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41320/mcm4-(minichromosome-maintenance-complex-component-4)