MDK (midkine)

2003-02-01  

Identity

HGNC
MDK
LOCATION
11p11.2
LOCUSID
4192
ALIAS
ARAP,MK,NEGF2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4192
MIM: 162096
HGNC: 6972
Ensembl: ENSG00000110492

Variants:

dbSNP: 4192
ClinVar: 4192
TCGA: ENSG00000110492
COSMIC: MDK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110492ENST00000359803P21741
ENSG00000110492ENST00000395565P21741
ENSG00000110492ENST00000395566P21741
ENSG00000110492ENST00000395569P21741
ENSG00000110492ENST00000405308P21741
ENSG00000110492ENST00000407067P21741
ENSG00000110492ENST00000441869C9JHA4
ENSG00000110492ENST00000489525E9PLM6
ENSG00000110492ENST00000533952E9PPJ5
ENSG00000110492ENST00000617138A0A087WXB6

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH2REACTOMER-HSA-1980145
NOTCH2 Activation and Transmission of Signal to the NucleusREACTOMER-HSA-2979096

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382478282024Midkine (MDK) in Hepatocellular Carcinoma: More than a Biomarker.0
382478282024Midkine (MDK) in Hepatocellular Carcinoma: More than a Biomarker.0
365923902023Long noncoding RNA HOTAIR and Midkine as biomarkers in thyroid cancer.1
367211122023Secreted proteins MDK, WFDC2, and CXCL14 as candidate biomarkers for early diagnosis of lung adenocarcinoma.3
372690572023Single-cell RNA-sequencing analysis reveals enhanced non-canonical neurotrophic factor signaling in the subacute phase of traumatic brain injury.3
377393422023Midkine characterization in human ovaries: potential new variants in follicles.0
378501192023Differential Production of Midkine and Pleiotrophin by Innate APCs upon Stimulation through Nucleic Acid-Sensing TLRs.0
382036252023Elevated Midkine Serum Levels Are Associated with Long-Term Survival in Critically Ill Patients.3
365923902023Long noncoding RNA HOTAIR and Midkine as biomarkers in thyroid cancer.1
367211122023Secreted proteins MDK, WFDC2, and CXCL14 as candidate biomarkers for early diagnosis of lung adenocarcinoma.3
372690572023Single-cell RNA-sequencing analysis reveals enhanced non-canonical neurotrophic factor signaling in the subacute phase of traumatic brain injury.3
377393422023Midkine characterization in human ovaries: potential new variants in follicles.0
378501192023Differential Production of Midkine and Pleiotrophin by Innate APCs upon Stimulation through Nucleic Acid-Sensing TLRs.0
382036252023Elevated Midkine Serum Levels Are Associated with Long-Term Survival in Critically Ill Patients.3
347398992022Serum midkine level might be a diagnostic tool for COVID19 disease in pregnancy: From the disease severity, hospitalization and disease progression respects.2

Citation

Dessen P

MDK (midkine)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41328/mdk-(midkine)