Identity
HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
BMFS6,HDMX,MDMX,MRP1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4194
MIM: 602704
HGNC: 6974
Ensembl: ENSG00000198625
Variants:
dbSNP: 4194
ClinVar: 4194
TCGA: ENSG00000198625
COSMIC: MDM4
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443560 | Breast Neoplasms | Disease | ClinicalAnnotation | associated | PD | 24958282 | |
| PA449383 | docetaxel | Chemical | ClinicalAnnotation | associated | PD | 24958282 | |
| PA449476 | epirubicin | Chemical | ClinicalAnnotation | associated | PD | 24958282 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38281029 | 2024 | MDM4 was associated with poor prognosis and tumor-immune infiltration of cancers. | 0 |
| 38374244 | 2024 | miR-34c-5p inhibited fibroblast proliferation, differentiation and epithelial-mesenchymal transition in benign airway stenosis via MDMX/p53 pathway. | 0 |
| 38281029 | 2024 | MDM4 was associated with poor prognosis and tumor-immune infiltration of cancers. | 0 |
| 38374244 | 2024 | miR-34c-5p inhibited fibroblast proliferation, differentiation and epithelial-mesenchymal transition in benign airway stenosis via MDMX/p53 pathway. | 0 |
| 35226569 | 2023 | MicroRNA miR-34a-5p inhibition restrains oxidative stress injury of macrophages by targeting MDM4. | 2 |
| 36546586 | 2023 | Reduced murine double minute 2 and 4 protein, but not messenger RNA, expression is associated with more severe disease in myelodysplastic syndromes and acute myeloblastic leukaemia. | 0 |
| 37086813 | 2023 | Murine double minute X plays a central role in leukemic transformation and may be a promising target for leukemia prevention strategies. | 1 |
| 37605571 | 2023 | LINC01094 accelerates the metastasis of hepatocellular carcinoma via the miR-26b-3p/MDM4 axis. | 0 |
| 35226569 | 2023 | MicroRNA miR-34a-5p inhibition restrains oxidative stress injury of macrophages by targeting MDM4. | 2 |
| 36546586 | 2023 | Reduced murine double minute 2 and 4 protein, but not messenger RNA, expression is associated with more severe disease in myelodysplastic syndromes and acute myeloblastic leukaemia. | 0 |
| 37086813 | 2023 | Murine double minute X plays a central role in leukemic transformation and may be a promising target for leukemia prevention strategies. | 1 |
| 37605571 | 2023 | LINC01094 accelerates the metastasis of hepatocellular carcinoma via the miR-26b-3p/MDM4 axis. | 0 |
| 35069793 | 2022 | Circular RNA CCDC66 Improves Murine Double Minute 4 (MDM4) Expression through Targeting miR-370 in Colorectal Cancer. | 5 |
| 35098683 | 2022 | MDM4 polymorphisms associated with the risk but not the prognosis of esophageal cancer in Cixian high-incidence region from northern China. | 2 |
| 35359247 | 2022 | (1)H, (15)N and (13)C backbone resonance assignments of the acidic domain of the human MDMX protein. | 2 |
Citation
Dessen P
MDM4 (MDM4 regulator of p53)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41329
