MDM4 (MDM4 regulator of p53)

2003-02-01 Affiliation

Identity

HGNC

MDM4

LOCATION

1q32.1

LOCUSID

4194

ALIAS

BMFS6,HDMX,MDMX,MRP1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4194
MIM: 602704
HGNC: 6974
Ensembl: ENSG00000198625

Variants:

dbSNP: 4194
ClinVar: 4194
TCGA: ENSG00000198625
COSMIC: MDM4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000198625	ENST00000367179	Q5T0Y2
ENSG00000198625	ENST00000367180	Q5T0Y4
ENSG00000198625	ENST00000367182	O15151
ENSG00000198625	ENST00000367182	A0A024R990
ENSG00000198625	ENST00000367183	O15151
ENSG00000198625	ENST00000391947	Q68DC0
ENSG00000198625	ENST00000444261	Q5T0Y3
ENSG00000198625	ENST00000454264	O15151
ENSG00000198625	ENST00000507825	Q68DC0
ENSG00000198625	ENST00000612738	A0A087WTR9
ENSG00000198625	ENST00000614459	A0A087WZ58
ENSG00000198625	ENST00000616250	A0A087WUE3
ENSG00000198625	ENST00000621032	Q6MZR7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
p53 signaling pathway	KEGG	ko04115
p53 signaling pathway	KEGG	hsa04115
MicroRNAs in cancer	KEGG	hsa05206
MicroRNAs in cancer	KEGG	ko05206
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle Checkpoints	REACTOME	R-HSA-69620
G1/S DNA Damage Checkpoints	REACTOME	R-HSA-69615
p53-Dependent G1/S DNA damage checkpoint	REACTOME	R-HSA-69580
p53-Dependent G1 DNA Damage Response	REACTOME	R-HSA-69563
Stabilization of p53	REACTOME	R-HSA-69541
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular Senescence	REACTOME	R-HSA-2559583
Oncogene Induced Senescence	REACTOME	R-HSA-2559585
Oxidative Stress Induced Senescence	REACTOME	R-HSA-2559580
Regulation of TP53 Activity	REACTOME	R-HSA-5633007
Regulation of TP53 Expression and Degradation	REACTOME	R-HSA-6806003
Regulation of TP53 Degradation	REACTOME	R-HSA-6804757
Regulation of TP53 Activity through Phosphorylation	REACTOME	R-HSA-6804756
Regulation of TP53 Activity through Methylation	REACTOME	R-HSA-6804760
Deubiquitination	REACTOME	R-HSA-5688426
Ub-specific processing proteases	REACTOME	R-HSA-5689880

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA443560	Breast Neoplasms	Disease	ClinicalAnnotation	associated	PD	24958282
PA449383	docetaxel	Chemical	ClinicalAnnotation	associated	PD	24958282
PA449476	epirubicin	Chemical	ClinicalAnnotation	associated	PD	24958282

References

Pubmed ID	Year	Title	Citations
38281029	2024	MDM4 was associated with poor prognosis and tumor-immune infiltration of cancers.	0
38374244	2024	miR-34c-5p inhibited fibroblast proliferation, differentiation and epithelial-mesenchymal transition in benign airway stenosis via MDMX/p53 pathway.	0
38281029	2024	MDM4 was associated with poor prognosis and tumor-immune infiltration of cancers.	0
38374244	2024	miR-34c-5p inhibited fibroblast proliferation, differentiation and epithelial-mesenchymal transition in benign airway stenosis via MDMX/p53 pathway.	0
35226569	2023	MicroRNA miR-34a-5p inhibition restrains oxidative stress injury of macrophages by targeting MDM4.	2
36546586	2023	Reduced murine double minute 2 and 4 protein, but not messenger RNA, expression is associated with more severe disease in myelodysplastic syndromes and acute myeloblastic leukaemia.	0
37086813	2023	Murine double minute X plays a central role in leukemic transformation and may be a promising target for leukemia prevention strategies.	1
37605571	2023	LINC01094 accelerates the metastasis of hepatocellular carcinoma via the miR-26b-3p/MDM4 axis.	0
35226569	2023	MicroRNA miR-34a-5p inhibition restrains oxidative stress injury of macrophages by targeting MDM4.	2
36546586	2023	Reduced murine double minute 2 and 4 protein, but not messenger RNA, expression is associated with more severe disease in myelodysplastic syndromes and acute myeloblastic leukaemia.	0
37086813	2023	Murine double minute X plays a central role in leukemic transformation and may be a promising target for leukemia prevention strategies.	1
37605571	2023	LINC01094 accelerates the metastasis of hepatocellular carcinoma via the miR-26b-3p/MDM4 axis.	0
35069793	2022	Circular RNA CCDC66 Improves Murine Double Minute 4 (MDM4) Expression through Targeting miR-370 in Colorectal Cancer.	5
35098683	2022	MDM4 polymorphisms associated with the risk but not the prognosis of esophageal cancer in Cixian high-incidence region from northern China.	2
35359247	2022	(1)H, (15)N and (13)C backbone resonance assignments of the acidic domain of the human MDMX protein.	2

Citation

Dessen P

MDM4 (MDM4 regulator of p53)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41329/mdm4-(mdm4-regulator-of-p53)