MDM4 (MDM4 regulator of p53)

2003-02-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
BMFS6,HDMX,MDMX,MRP1
FUSION GENES

Other Information

Locus ID:

NCBI: 4194
MIM: 602704
HGNC: 6974
Ensembl: ENSG00000198625

Variants:

dbSNP: 4194
ClinVar: 4194
TCGA: ENSG00000198625
COSMIC: MDM4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198625ENST00000367179Q5T0Y2
ENSG00000198625ENST00000367180Q5T0Y4
ENSG00000198625ENST00000367182O15151
ENSG00000198625ENST00000367182A0A024R990
ENSG00000198625ENST00000367183O15151
ENSG00000198625ENST00000391947Q68DC0
ENSG00000198625ENST00000444261Q5T0Y3
ENSG00000198625ENST00000454264O15151
ENSG00000198625ENST00000507825Q68DC0
ENSG00000198625ENST00000612738A0A087WTR9
ENSG00000198625ENST00000614459A0A087WZ58
ENSG00000198625ENST00000616250A0A087WUE3
ENSG00000198625ENST00000621032Q6MZR7

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
p53 signaling pathwayKEGGko04115
p53 signaling pathwayKEGGhsa04115
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G1/S DNA Damage CheckpointsREACTOMER-HSA-69615
p53-Dependent G1/S DNA damage checkpointREACTOMER-HSA-69580
p53-Dependent G1 DNA Damage ResponseREACTOMER-HSA-69563
Stabilization of p53REACTOMER-HSA-69541
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oncogene Induced SenescenceREACTOMER-HSA-2559585
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Expression and DegradationREACTOMER-HSA-6806003
Regulation of TP53 DegradationREACTOMER-HSA-6804757
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756
Regulation of TP53 Activity through MethylationREACTOMER-HSA-6804760
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD24958282
PA449383docetaxelChemicalClinicalAnnotationassociatedPD24958282
PA449476epirubicinChemicalClinicalAnnotationassociatedPD24958282

References

Pubmed IDYearTitleCitations
170800832006Inactivation of the p53 pathway in retinoblastoma.210
201727292010The p53 orchestra: Mdm2 and Mdmx set the tone.195
283519302017Hyperprogressors after Immunotherapy: Analysis of Genomic Alterations Associated with Accelerated Growth Rate.172
239464212013Stapled α-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy.163
151991392004Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity.125
128609992003MDM2 promotes ubiquitination and degradation of MDMX.120
228206432012MDM4 is a key therapeutic target in cutaneous melanoma.113
119534232002Mutual dependence of MDM2 and MDMX in their functional inactivation of p53.112
161633882005ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.112
192554502009Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.105

Citation

Dessen P

MDM4 (MDM4 regulator of p53)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41329/mdm4-(mdm4-regulator-of-p53)