Identity
HGNC
LOCATION
15q26.1
LOCUSID
ALIAS
BA46,EDIL1,HMFG,HsT19888,MFG-E8,MFGM,OAcGD3S,SED1,SPAG10,hP47
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4240
MIM: 602281
HGNC: 7036
Ensembl: ENSG00000140545
Variants:
dbSNP: 4240
ClinVar: 4240
TCGA: ENSG00000140545
COSMIC: MFGE8
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism of proteins | REACTOME | R-HSA-392499 |
| Amyloid fiber formation | REACTOME | R-HSA-977225 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38173019 | 2024 | Lactadherin immunoblockade in small extracellular vesicles inhibits sEV-mediated increase of pro-metastatic capacities. | 1 |
| 38199575 | 2024 | PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin. | 1 |
| 38332689 | 2024 | Potent CTLs can be induced against tumor cells in an environment of lower levels of systemic MFG-E8. | 1 |
| 38431242 | 2024 | MFG-E8 induces epithelial-mesenchymal transition and anoikis resistance to promote the metastasis of pancreatic cancer cells. | 0 |
| 38173019 | 2024 | Lactadherin immunoblockade in small extracellular vesicles inhibits sEV-mediated increase of pro-metastatic capacities. | 1 |
| 38199575 | 2024 | PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin. | 1 |
| 38332689 | 2024 | Potent CTLs can be induced against tumor cells in an environment of lower levels of systemic MFG-E8. | 1 |
| 38431242 | 2024 | MFG-E8 induces epithelial-mesenchymal transition and anoikis resistance to promote the metastasis of pancreatic cancer cells. | 0 |
| 36659830 | 2023 | CircSMAD2 accelerates endometrial cancer cell proliferation and metastasis by regulating the miR-1277-5p/MFGE8 axis. | 2 |
| 37652017 | 2023 | Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8. | 10 |
| 37816055 | 2023 | Targeting MFGE8 secreted by cancer-associated fibroblasts blocks angiogenesis and metastasis in esophageal squamous cell carcinoma. | 3 |
| 37914766 | 2023 | Transcriptomic analyses reveal proinflammatory activation of human brain microvascular endothelial cells by aging-associated peptide medin and reversal by nanoliposomes. | 0 |
| 37933040 | 2023 | Expression and clinical association of MFG-E8 and TAM receptors in diabetic patients with different stages of microvascular complication: An experimental study. | 0 |
| 36659830 | 2023 | CircSMAD2 accelerates endometrial cancer cell proliferation and metastasis by regulating the miR-1277-5p/MFGE8 axis. | 2 |
| 37652017 | 2023 | Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8. | 10 |
Citation
Dessen P
MFGE8 (milk fat globule EGF and factor V/VIII domain containing)
Atlas Genet Cytogenet Oncol Haematol. 2003-12-01
Online version: http://atlasgeneticsoncology.org/gene/41342/mfge8-(milk-fat-globule-egf-and-factor-v-viii-domain-containing)
