Identity
HGNC
LOCATION
1p36.22
LOCUSID
ALIAS
CMT2A,CMT2A2,CMT2A2A,CMT2A2B,CPRP1,HMSN6A,HSG,MARF
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9927
MIM: 608507
HGNC: 16877
Ensembl: ENSG00000116688
Variants:
dbSNP: 9927
ClinVar: 9927
TCGA: ENSG00000116688
COSMIC: MFN2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000116688 | ENST00000235329 | O95140 |
| ENSG00000116688 | ENST00000412236 | Q5JXC5 |
| ENSG00000116688 | ENST00000444836 | O95140 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37436713 | 2024 | Evaluation of the role of mitofusin-1 and mitofusin-2 in periodontal disease. | 0 |
| 38092249 | 2024 | CMT2A-linked MFN2 mutation, T206I promotes mitochondrial hyperfusion and predisposes cells towards mitophagy. | 0 |
| 38177900 | 2024 | MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion. | 1 |
| 38430028 | 2024 | Declined circular RNA mitofusin 2 constrains the deterioration of Wilms tumor via modulating microRNA-372-3p/transforming growth factor-β receptor type 2 axis. | 0 |
| 38449303 | 2024 | Mitofusin-2 enhances cervical cancer progression through Wnt/β-catenin signaling. | 0 |
| 38480904 | 2024 | MFN2 suppresses the accumulation of lipid droplets and the progression of clear cell renal cell carcinoma. | 1 |
| 38743133 | 2024 | lncRNA ZNF593-AS inhibits cardiac hypertrophy and myocardial remodeling by upregulating Mfn2 expression. | 0 |
| 37436713 | 2024 | Evaluation of the role of mitofusin-1 and mitofusin-2 in periodontal disease. | 0 |
| 38092249 | 2024 | CMT2A-linked MFN2 mutation, T206I promotes mitochondrial hyperfusion and predisposes cells towards mitophagy. | 0 |
| 38177900 | 2024 | MTCH2 cooperates with MFN2 and lysophosphatidic acid synthesis to sustain mitochondrial fusion. | 1 |
| 38430028 | 2024 | Declined circular RNA mitofusin 2 constrains the deterioration of Wilms tumor via modulating microRNA-372-3p/transforming growth factor-β receptor type 2 axis. | 0 |
| 38449303 | 2024 | Mitofusin-2 enhances cervical cancer progression through Wnt/β-catenin signaling. | 0 |
| 38480904 | 2024 | MFN2 suppresses the accumulation of lipid droplets and the progression of clear cell renal cell carcinoma. | 1 |
| 38743133 | 2024 | lncRNA ZNF593-AS inhibits cardiac hypertrophy and myocardial remodeling by upregulating Mfn2 expression. | 0 |
| 35994048 | 2023 | Mitofusin 2 mutation drives cell proliferation in Charcot-Marie-Tooth 2A fibroblasts. | 2 |
Citation
Dessen P
MFN2 (mitofusin 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/41345/mfn2-(mitofusin-2)
