MFNG (MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)

2003-02-01  

Identity

HGNC
MFNG
LOCATION
22q13.1
LOCUSID
4242
ALIAS
-

Other Information

Locus ID:

NCBI: 4242
MIM: 602577
HGNC: 7038
Ensembl: ENSG00000100060

Variants:

dbSNP: 4242
ClinVar: 4242
TCGA: ENSG00000100060
COSMIC: MFNG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100060ENST00000356998O00587
ENSG00000100060ENST00000416983O00587
ENSG00000100060ENST00000424765A9UJP9
ENSG00000100060ENST00000430411F8WE05
ENSG00000100060ENST00000436341A9UJQ1
ENSG00000100060ENST00000438891F8WE21
ENSG00000100060ENST00000442496A0A1B0GX02
ENSG00000100060ENST00000454291H0Y6Q9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Other types of O-glycan biosynthesisKEGGko00514
Notch signaling pathwayKEGGko04330
Other types of O-glycan biosynthesisKEGGhsa00514
Notch signaling pathwayKEGGhsa04330
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Pre-NOTCH Expression and ProcessingREACTOMER-HSA-1912422
Pre-NOTCH Processing in GolgiREACTOMER-HSA-1912420

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
374960532023MFNG is an independent prognostic marker for osteosarcoma.1
374960532023MFNG is an independent prognostic marker for osteosarcoma.1
343710132021Nuclear and stromal expression of Manic fringe in renal cell carcinoma.4
343710132021Nuclear and stromal expression of Manic fringe in renal cell carcinoma.4
300653042018Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells.14
300653042018Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells.14
258088692015Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction.39
258088692015Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction.39
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.37
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.37
152804772004Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation.20
152804772004Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation.20

Citation

Dessen P

MFNG (MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41346/mfng-(mfng-o-fucosylpeptide-3-beta-n-acetylglucosaminyltransferase)