MGST1 (microsomal glutathione S-transferase 1)

2003-06-01  

Identity

HGNC
LOCATION
12p12.3
LOCUSID
ALIAS
GST12,MGST,MGST-I
FUSION GENES

Other Information

Locus ID:

NCBI: 4257
MIM: 138330
HGNC: 7061
Ensembl: ENSG00000008394

Variants:

dbSNP: 4257
ClinVar: 4257
TCGA: ENSG00000008394
COSMIC: MGST1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000008394ENST00000010404P10620
ENSG00000008394ENST00000010404A0A024RAX2
ENSG00000008394ENST00000396207P10620
ENSG00000008394ENST00000396207A0A024RAX2
ENSG00000008394ENST00000396209P10620
ENSG00000008394ENST00000396209A0A024RAX2
ENSG00000008394ENST00000396210P10620
ENSG00000008394ENST00000396210A0A024RAX2
ENSG00000008394ENST00000535309P10620
ENSG00000008394ENST00000536371F5H7F6
ENSG00000008394ENST00000538885F5GX73
ENSG00000008394ENST00000540056F5H613
ENSG00000008394ENST00000540126F5H6X2
ENSG00000008394ENST00000543076F5H760

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glutathione metabolismKEGGhsa00480
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Aflatoxin activation and detoxificationREACTOMER-HSA-5423646
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
Neutrophil degranulationREACTOMER-HSA-6798695
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163849812006Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6.64
207279662010Multiple roles of microsomal glutathione transferase 1 in cellular protection: a mechanistic study.26
123593562002Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk.15
177147642007Age-related transcription levels of KU70, MGST1 and BIK in CD34+ hematopoietic stem and progenitor cells.10
274860972017Germline variation in inflammation-related pathways and risk of Barrett's oesophagus and oesophageal adenocarcinoma.9
174839572007Microsomal glutathione S-transferase gene polymorphisms and colorectal cancer risk in a Han Chinese population.8
153383732004Genetic analysis of the glutathione s-transferase genes MGST1, GSTM3, GSTT1, and GSTM1 in patients with hereditary pancreatitis.5
238050412013Quantitative analysis of SOD2, ALDH1A1 and MGST1 messenger ribonucleic acid in anterior lens epithelium of patients with pseudoexfoliation syndrome.5
297139842018Biomarkers of Barrett's Esophagus: From the Laboratory to Clinical Practice.5
115870732001Catalog of 46 single-nucleotide polymorphisms (SNPs) in the microsomal glutathione S-transferase 1 (MGST1) gene.3

Citation

Dessen P

MGST1 (microsomal glutathione S-transferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41361/mgst1-(microsomal-glutathione-s-transferase-1)