MKNK1 (MAPK interacting serine/threonine kinase 1)

2003-11-01  

Identity

HGNC
MKNK1
LOCATION
1p33
LOCUSID
8569
ALIAS
MNK1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8569
MIM: 606724
HGNC: 7110
Ensembl: ENSG00000079277

Variants:

dbSNP: 8569
ClinVar: 8569
TCGA: ENSG00000079277
COSMIC: MKNK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000079277ENST00000341183Q7Z319
ENSG00000079277ENST00000371945A0A499FJN1
ENSG00000079277ENST00000371946A0A499FIS5
ENSG00000079277ENST00000428112A0A499FJS1
ENSG00000079277ENST00000465783E9PN34
ENSG00000079277ENST00000474868E9PN34
ENSG00000079277ENST00000496619E9PIA0
ENSG00000079277ENST00000524749H0YE67
ENSG00000079277ENST00000526513E9PSC9
ENSG00000079277ENST00000528077E9PMM8
ENSG00000079277ENST00000529170E9PLE7
ENSG00000079277ENST00000531355E9PQ26
ENSG00000079277ENST00000531769E9PSE0
ENSG00000079277ENST00000532110E9PII5
ENSG00000079277ENST00000649800Q9BUB5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Insulin signaling pathwayKEGGko04910
MAPK signaling pathwayKEGGhsa04010
Insulin signaling pathwayKEGGhsa04910
HIF-1 signaling pathwayKEGGhsa04066
Signal TransductionREACTOMER-HSA-162582
Signaling by FGFRREACTOMER-HSA-190236
Signaling by FGFR1REACTOMER-HSA-5654736
Negative regulation of FGFR1 signalingREACTOMER-HSA-5654726
Spry regulation of FGF signalingREACTOMER-HSA-1295596
Signaling by FGFR2REACTOMER-HSA-5654738
Negative regulation of FGFR2 signalingREACTOMER-HSA-5654727
Signaling by FGFR3REACTOMER-HSA-5654741
Negative regulation of FGFR3 signalingREACTOMER-HSA-5654732
Signaling by FGFR4REACTOMER-HSA-5654743
Negative regulation of FGFR4 signalingREACTOMER-HSA-5654733

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
367646012023MNK1 and MNK2 Expression in the Human Dorsal Root and Trigeminal Ganglion.3
367646012023MNK1 and MNK2 Expression in the Human Dorsal Root and Trigeminal Ganglion.3
335640732021MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma.8
339716272021Identification of potential autophagy-associated lncRNA in prostate cancer.5
341155742021MAPK interacting serine/threonine kinase 1 (MKNK1), one target gene of miR-223-3p, correlates with neutrophils in sepsis based on bioinformatic analysis.3
348340182021miR-370-3p Regulates Adipogenesis through Targeting Mknk1.3
335640732021MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma.8
339716272021Identification of potential autophagy-associated lncRNA in prostate cancer.5
341155742021MAPK interacting serine/threonine kinase 1 (MKNK1), one target gene of miR-223-3p, correlates with neutrophils in sepsis based on bioinformatic analysis.3
348340182021miR-370-3p Regulates Adipogenesis through Targeting Mknk1.3
317820832020Eukaryotic initiation factor 4E is a novel effector of mTORC1 signaling pathway in cross talk with Mnk1.6
318942992020FLI1 promotes protein translation via the transcriptional regulation of MKNK1 expression.1
321326512020MNK1 signaling induces an ANGPTL4-mediated gene signature to drive melanoma progression.10
317820832020Eukaryotic initiation factor 4E is a novel effector of mTORC1 signaling pathway in cross talk with Mnk1.6
318942992020FLI1 promotes protein translation via the transcriptional regulation of MKNK1 expression.1

Citation

Dessen P

MKNK1 (MAPK interacting serine/threonine kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41371