MKNK1 (MAPK interacting serine/threonine kinase 1)

2003-11-01  

Identity

HGNC
MKNK1
LOCATION
1p33
LOCUSID
8569
ALIAS
MNK1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8569
MIM: 606724
HGNC: 7110
Ensembl: ENSG00000079277

Variants:

dbSNP: 8569
ClinVar: 8569
TCGA: ENSG00000079277
COSMIC: MKNK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000079277ENST00000341183Q7Z319
ENSG00000079277ENST00000371945A0A499FJN1
ENSG00000079277ENST00000371946A0A499FIS5
ENSG00000079277ENST00000428112A0A499FJS1
ENSG00000079277ENST00000465783E9PN34
ENSG00000079277ENST00000474868E9PN34
ENSG00000079277ENST00000496619E9PIA0
ENSG00000079277ENST00000524749H0YE67
ENSG00000079277ENST00000526513E9PSC9
ENSG00000079277ENST00000528077E9PMM8
ENSG00000079277ENST00000529170E9PLE7
ENSG00000079277ENST00000531355E9PQ26
ENSG00000079277ENST00000531769E9PSE0
ENSG00000079277ENST00000532110E9PII5
ENSG00000079277ENST00000649800Q9BUB5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Insulin signaling pathwayKEGGko04910
MAPK signaling pathwayKEGGhsa04010
Insulin signaling pathwayKEGGhsa04910
HIF-1 signaling pathwayKEGGhsa04066
Signal TransductionREACTOMER-HSA-162582
Signaling by FGFRREACTOMER-HSA-190236
Signaling by FGFR1REACTOMER-HSA-5654736
Negative regulation of FGFR1 signalingREACTOMER-HSA-5654726
Spry regulation of FGF signalingREACTOMER-HSA-1295596
Signaling by FGFR2REACTOMER-HSA-5654738
Negative regulation of FGFR2 signalingREACTOMER-HSA-5654727
Signaling by FGFR3REACTOMER-HSA-5654741
Negative regulation of FGFR3 signalingREACTOMER-HSA-5654732
Signaling by FGFR4REACTOMER-HSA-5654743
Negative regulation of FGFR4 signalingREACTOMER-HSA-5654733

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
261476852015Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation.70
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
177240792007Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation.54
214064052011MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma.50
237375032013Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function.39
215763612011Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.34
244012752014MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.28
254032302014MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.27
164790082006Regulation of sprouty stability by Mnk1-dependent phosphorylation.25
206863662010The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival.25

Citation

Dessen P

MKNK1 (MAPK interacting serine/threonine kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41371/mknk1-(mapk-interacting-serine-threonine-kinase-1)