Identity
HGNC
LOCATION
7q36.1
LOCUSID
ALIAS
HALR,KLEFS2,MLL3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 58508
MIM: 606833
HGNC: 13726
Ensembl: ENSG00000055609
Variants:
dbSNP: 58508
ClinVar: 58508
TCGA: ENSG00000055609
COSMIC: KMT2C
RNA/Proteins
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38146907 | 2024 | A novel 11 base pair deletion in KMT2C resulting in Kleefstra syndrome 2. | 1 |
| 38146907 | 2024 | A novel 11 base pair deletion in KMT2C resulting in Kleefstra syndrome 2. | 1 |
| 35870559 | 2023 | KMT2C Induced by FABP5P3 Aggravates Keratinocyte Hyperproliferation and Psoriasiform Skin Inflammation by Upregulating the Transcription of PIK3R3. | 6 |
| 36601880 | 2023 | Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer. | 4 |
| 36604594 | 2023 | MLL3 loss drives metastasis by promoting a hybrid epithelial-mesenchymal transition state. | 12 |
| 37226099 | 2023 | Association of MLL3 and TGF-β signaling gene polymorphisms with the susceptibility and prognostic outcomes of Stanford type B aortic dissection : MLL3 with TGF-β signal pathway association with Stanford type B AD. | 0 |
| 37261974 | 2023 | MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer. | 3 |
| 37415738 | 2023 | Mutations in epigenetic regulator KMT2C detected by liquid biopsy are associated with worse survival in prostate cancer patients. | 3 |
| 35870559 | 2023 | KMT2C Induced by FABP5P3 Aggravates Keratinocyte Hyperproliferation and Psoriasiform Skin Inflammation by Upregulating the Transcription of PIK3R3. | 6 |
| 36601880 | 2023 | Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer. | 4 |
| 36604594 | 2023 | MLL3 loss drives metastasis by promoting a hybrid epithelial-mesenchymal transition state. | 12 |
| 37226099 | 2023 | Association of MLL3 and TGF-β signaling gene polymorphisms with the susceptibility and prognostic outcomes of Stanford type B aortic dissection : MLL3 with TGF-β signal pathway association with Stanford type B AD. | 0 |
| 37261974 | 2023 | MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer. | 3 |
| 37415738 | 2023 | Mutations in epigenetic regulator KMT2C detected by liquid biopsy are associated with worse survival in prostate cancer patients. | 3 |
| 35322299 | 2022 | Histone methyltransferase KMT2C plays an oncogenic role in prostate cancer. | 2 |
Citation
Dessen P
KMT2C (lysine methyltransferase 2C)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41376
