GSDMC (gasdermin C)

2003-12-01  

Identity

HGNC
GSDMC
LOCATION
8q24.21
LOCUSID
56169
ALIAS
MLZE
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56169
MIM: 608384
HGNC: 7151
Ensembl: ENSG00000147697

Variants:

dbSNP: 56169
ClinVar: 56169
TCGA: ENSG00000147697
COSMIC: GSDMC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147697ENST00000276708Q9BYG8
ENSG00000147697ENST00000619643Q9BYG8

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379190592023The Pyroptosis-Related Signature Composed of GSDMC Predicts Prognosis and Contributes to Growth and Metastasis of Hepatocellular Carcinoma.0
379190592023The Pyroptosis-Related Signature Composed of GSDMC Predicts Prognosis and Contributes to Growth and Metastasis of Hepatocellular Carcinoma.0
361991462022System analysis based on the pyroptosis-related genes identifies GSDMC as a novel therapy target for pancreatic adenocarcinoma.12
361991462022System analysis based on the pyroptosis-related genes identifies GSDMC as a novel therapy target for pancreatic adenocarcinoma.12
347784522021High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer.10
347784522021High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer.10
319396222020Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma.63
323334992020Association of GSDMC polymorphisms with lumbar disc herniation among Chinese Han population.8
329292012020PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.392
332736352020Two GWAS-identified variants are associated with lumbar spinal stenosis and Gasdermin-C expression in Chinese population.14
319396222020Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma.63
323334992020Association of GSDMC polymorphisms with lumbar disc herniation among Chinese Han population.8
329292012020PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.392
332736352020Two GWAS-identified variants are associated with lumbar spinal stenosis and Gasdermin-C expression in Chinese population.14
294288152018Gasdermin C is induced by ultraviolet light and contributes to MMP-1 expression via activation of ERK and JNK pathways.24

Citation

Dessen P

GSDMC (gasdermin C)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41384/gsdmc-(gasdermin-c)