Identity
HGNC
LOCATION
11q22.2
LOCUSID
ALIAS
HME,ME,MME,MMP-12
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4321
MIM: 601046
HGNC: 7158
Ensembl: ENSG00000262406
Variants:
dbSNP: 4321
ClinVar: 4321
TCGA: ENSG00000262406
COSMIC: MMP12
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000262406 | ENST00000571244 | P39900 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Extracellular matrix organization | REACTOME | R-HSA-1474244 |
| Degradation of the extracellular matrix | REACTOME | R-HSA-1474228 |
| Collagen degradation | REACTOME | R-HSA-1442490 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38288346 | 2024 | MTOR Suppresses Cigarette Smoke-Induced Airway Inflammation and MMP12 Expression in Macrophage in Chronic Obstructive Pulmonary Disease. | 0 |
| 38632141 | 2024 | HOXB9 promotes laryngeal squamous cell carcinoma progression by upregulating MMP12. | 0 |
| 38652053 | 2024 | Integrated Exploration of Epigenetic Dysregulation Reveals a Stemness/EMT Subtype and MMP12 Linked to the Progression and Prognosis in Hepatocellular Carcinoma. | 0 |
| 38771844 | 2024 | SNP-SNP positive interaction between MMP2 and MMP12 increases the risk of COPD. | 0 |
| 38288346 | 2024 | MTOR Suppresses Cigarette Smoke-Induced Airway Inflammation and MMP12 Expression in Macrophage in Chronic Obstructive Pulmonary Disease. | 0 |
| 38632141 | 2024 | HOXB9 promotes laryngeal squamous cell carcinoma progression by upregulating MMP12. | 0 |
| 38652053 | 2024 | Integrated Exploration of Epigenetic Dysregulation Reveals a Stemness/EMT Subtype and MMP12 Linked to the Progression and Prognosis in Hepatocellular Carcinoma. | 0 |
| 38771844 | 2024 | SNP-SNP positive interaction between MMP2 and MMP12 increases the risk of COPD. | 0 |
| 37812024 | 2023 | Prognostic and clinicopathological significance of MMP12 in various cancers: a meta-analysis and bioinformatics analysis. | 2 |
| 37812024 | 2023 | Prognostic and clinicopathological significance of MMP12 in various cancers: a meta-analysis and bioinformatics analysis. | 2 |
| 34812434 | 2022 | Evaluation of MMP-12 expression in chronic rhinosinusitis with nasal polyposis. | 2 |
| 34894337 | 2022 | Matrix metalloproteinase 12 is an independent prognostic factor predicting postoperative relapse of conventional renal cell carcinoma - a short report. | 2 |
| 35313071 | 2022 | DRP1 contributes to head and neck cancer progression and induces glycolysis through modulated FOXM1/MMP12 axis. | 9 |
| 35442508 | 2022 | Matrix metalloproteinase 12 (MMP12) as an adverse prognostic biomarker of vascular invasion in hepatic cell carcinoma. | 5 |
| 35576280 | 2022 | Analytical Study Of Salivary Mmp-12 Expression In Oral Submucous Fibrosis. | 1 |
Citation
Dessen P
MMP12 (matrix metallopeptidase 12)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41389/mmp12-(matrix-metallopeptidase-12)
