MMP12 (matrix metallopeptidase 12)

2003-02-01  

Identity

HGNC
MMP12
LOCATION
11q22.2
LOCUSID
4321
ALIAS
HME,ME,MME,MMP-12
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4321
MIM: 601046
HGNC: 7158
Ensembl: ENSG00000262406

Variants:

dbSNP: 4321
ClinVar: 4321
TCGA: ENSG00000262406
COSMIC: MMP12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000262406ENST00000571244P39900

Expression (GTEx)

0
1
2
3
4
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Collagen degradationREACTOMER-HSA-1442490

References

Pubmed IDYearTitleCitations
382883462024MTOR Suppresses Cigarette Smoke-Induced Airway Inflammation and MMP12 Expression in Macrophage in Chronic Obstructive Pulmonary Disease.0
386321412024HOXB9 promotes laryngeal squamous cell carcinoma progression by upregulating MMP12.0
386520532024Integrated Exploration of Epigenetic Dysregulation Reveals a Stemness/EMT Subtype and MMP12 Linked to the Progression and Prognosis in Hepatocellular Carcinoma.0
387718442024SNP-SNP positive interaction between MMP2 and MMP12 increases the risk of COPD.0
382883462024MTOR Suppresses Cigarette Smoke-Induced Airway Inflammation and MMP12 Expression in Macrophage in Chronic Obstructive Pulmonary Disease.0
386321412024HOXB9 promotes laryngeal squamous cell carcinoma progression by upregulating MMP12.0
386520532024Integrated Exploration of Epigenetic Dysregulation Reveals a Stemness/EMT Subtype and MMP12 Linked to the Progression and Prognosis in Hepatocellular Carcinoma.0
387718442024SNP-SNP positive interaction between MMP2 and MMP12 increases the risk of COPD.0
378120242023Prognostic and clinicopathological significance of MMP12 in various cancers: a meta-analysis and bioinformatics analysis.2
378120242023Prognostic and clinicopathological significance of MMP12 in various cancers: a meta-analysis and bioinformatics analysis.2
348124342022Evaluation of MMP-12 expression in chronic rhinosinusitis with nasal polyposis.2
348943372022Matrix metalloproteinase 12 is an independent prognostic factor predicting postoperative relapse of conventional renal cell carcinoma - a short report.2
353130712022DRP1 contributes to head and neck cancer progression and induces glycolysis through modulated FOXM1/MMP12 axis.9
354425082022Matrix metalloproteinase 12 (MMP12) as an adverse prognostic biomarker of vascular invasion in hepatic cell carcinoma.5
355762802022Analytical Study Of Salivary Mmp-12 Expression In Oral Submucous Fibrosis.1

Citation

Dessen P

MMP12 (matrix metallopeptidase 12)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41389/mmp12-(matrix-metallopeptidase-12)