MMP3 (matrix metallopeptidase 3)

2003-02-01  

Identity

HGNC
LOCATION
11q22.2
LOCUSID
ALIAS
CHDS6,MMP-3,SL-1,STMY,STMY1,STR1
FUSION GENES

Other Information

Locus ID:

NCBI: 4314
MIM: 185250
HGNC: 7173
Ensembl: ENSG00000149968

Variants:

dbSNP: 4314
ClinVar: 4314
TCGA: ENSG00000149968
COSMIC: MMP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149968ENST00000299855P08254
ENSG00000149968ENST00000434103H7C139
ENSG00000149968ENST00000524478E9PKX2

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
EGFR Transactivation by GastrinREACTOMER-HSA-2179392
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Assembly of collagen fibrils and other multimeric structuresREACTOMER-HSA-2022090
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389
Collagen degradationREACTOMER-HSA-1442490
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443796Coronary Artery DiseaseDiseaseClinicalAnnotationassociatedPD10190398
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD
PA448970chlorthalidoneChemicalClinicalAnnotationassociatedPD
PA450242lisinoprilChemicalClinicalAnnotationassociatedPD
PA451089pravastatinChemicalClinicalAnnotationassociatedPD10190398

References

Pubmed IDYearTitleCitations
374426412024MMP3 single-nucleotide polymorphisms are associated with noncontact ACL injuries in competing high-level athletes.0
384546452024Smooth muscle cell-specific matrix metalloproteinase 3 deletion reduces osteogenic transformation and medial artery calcification.1
390004352024Growth Differentiation Factor 15 and Matrix Metalloproteinase 3 in Plasma as Biomarkers for Neuropathy and Nephropathy in Type 1 Diabetes.0
374426412024MMP3 single-nucleotide polymorphisms are associated with noncontact ACL injuries in competing high-level athletes.0
384546452024Smooth muscle cell-specific matrix metalloproteinase 3 deletion reduces osteogenic transformation and medial artery calcification.1
390004352024Growth Differentiation Factor 15 and Matrix Metalloproteinase 3 in Plasma as Biomarkers for Neuropathy and Nephropathy in Type 1 Diabetes.0
348603352023Candidate Gene of NOS3, MMP3, AGT, and AGT1R and Pathway Analyses for Platelet Reactivity and Clinical Outcomes of Repeat Revascularization After First PCI in Chinese Patients.0
363197842023Association of the matrix metalloproteinases (MMPs) family gene polymorphisms and the risk of coronavirus disease 2019 (COVID-19); implications of contribution for development of neurological symptoms in the COVID-19 patients.4
366404922023Over-expression of USP15/MMP3 predict poor prognosis and promote growth, migration in non-small cell lung cancer cells.4
367399772023Comparative evaluation of the trabecular structure of the mandibular condyle, the levels of salivary cortisol, MMP-3, TNF-α, IL-1β in individuals with and without temporomandibular joint disorder.0
368083522023The promoter methylations of the autoimmune regulator (AIRE) gene and matrix metalloproteinase-3 (MMP-3) gene may have a role in gestational diabetes mellitus.0
371761062023The Transcriptomic Profiles of ESR1 and MMP3 Stratify the Risk of Biochemical Recurrence in Primary Prostate Cancer beyond Clinical Features.4
374712172023Association of MMP3 gene polymorphism and sex on recovery of muscle strength after eccentric exercise.0
375516832023MMP-3 -1171 5A/6A promoter polymorphism and cancer susceptibility: an updated meta-analysis and trial sequential analysis.0
379860832023Association of MMP3, MMP14, and MMP25 gene polymorphisms with cerebral stroke risk: a case-control study.0

Citation

Dessen P

MMP3 (matrix metallopeptidase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41406/mmp3-(matrix-metallopeptidase-3)