MMP8 (matrix metallopeptidase 8)

2003-06-01  

Identity

HGNC
LOCATION
11q22.2
LOCUSID
ALIAS
CLG1,HNC,MMP-8,PMNL-CL

Other Information

Locus ID:

NCBI: 4317
MIM: 120355
HGNC: 7175
Ensembl: ENSG00000118113

Variants:

dbSNP: 4317
ClinVar: 4317
TCGA: ENSG00000118113
COSMIC: MMP8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118113ENST00000236826P22894
ENSG00000118113ENST00000438475H7C1M3
ENSG00000118113ENST00000528662E9PL87
ENSG00000118113ENST00000531168E9PJB3
ENSG00000118113ENST00000532799E9PIY7
ENSG00000118113ENST00000533258E9PJB3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389
Collagen degradationREACTOMER-HSA-1442490
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
151871632004Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase.69
193300282009Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.68
204428662010Neisseria meningitidis induces brain microvascular endothelial cell detachment from the matrix and cleavage of occludin: a role for MMP-8.59
153674872004Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM).44
153674872004Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM).44
200425852010Matrix metalloproteinase-8 inactivates macrophage inflammatory protein-1 alpha to reduce acute lung inflammation and injury in mice.42
164320742006Matrix metalloproteinase-8 and -9 are increased at the site of abdominal aortic aneurysm rupture.41
145502882003Carboxyterminal cleavage of the chemokines MIG and IP-10 by gelatinase B and neutrophil collagenase.39
206738682010A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).36

Citation

Dessen P

MMP8 (matrix metallopeptidase 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41407/mmp8-(matrix-metallopeptidase-8)