Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4352
MIM: 159530
HGNC: 7217
Ensembl: ENSG00000117400
Variants:
dbSNP: 4352
ClinVar: 4352
TCGA: ENSG00000117400
COSMIC: MPL
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000117400 | ENST00000372470 | P40238 |
| ENSG00000117400 | ENST00000413998 | Q5JUY5 |
| ENSG00000117400 | ENST00000643351 | A0A2R8YE13 |
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37883794 | 2024 | PF4 activates the c-Mpl-Jak2 pathway in platelets. | 2 |
| 37939832 | 2024 | Germline MPL mutations may be a rare cause of "triple-negative" thrombocytosis. | 0 |
| 37883794 | 2024 | PF4 activates the c-Mpl-Jak2 pathway in platelets. | 2 |
| 37939832 | 2024 | Germline MPL mutations may be a rare cause of "triple-negative" thrombocytosis. | 0 |
| 35924408 | 2023 | Clonal evolution in hereditary thrombocytosis with MPL T487A mutation. | 0 |
| 36031433 | 2023 | Novel modes of MPL activation in triple-negative myeloproliferative neoplasms. | 0 |
| 36476017 | 2023 | Frequency of JAK2V617F, MPL and CALR driver mutations and associated clinical characteristics in a Norwegian patient cohort with myeloproliferative neoplasms. | 0 |
| 37378567 | 2023 | MPL gene mutation is a possible risk factor for thrombosis in patients with essential thrombocythemia in Japan. | 1 |
| 37438490 | 2023 | Genomic and computational analysis of four novel variants of MPL gene in Congenital Amegakaryocytic Thrombocytopenia. | 0 |
| 37610030 | 2023 | A novel mutation in MECOM affects MPL regulation in vitro and results in thrombocytopenia and bone marrow failure. | 1 |
| 37883814 | 2023 | Assessment of intestinal status in MPL(W515L) mutant myeloproliferative neoplasms mice model. | 0 |
| 38111518 | 2023 | JAK2, CALR, and MPL Mutation Profiles in Colombian patients with BCR-ABL Negative Myeloproliferative Neoplasms. | 1 |
| 35924408 | 2023 | Clonal evolution in hereditary thrombocytosis with MPL T487A mutation. | 0 |
| 36031433 | 2023 | Novel modes of MPL activation in triple-negative myeloproliferative neoplasms. | 0 |
| 36476017 | 2023 | Frequency of JAK2V617F, MPL and CALR driver mutations and associated clinical characteristics in a Norwegian patient cohort with myeloproliferative neoplasms. | 0 |
Citation
Dessen P
MPL (MPL proto-oncogene, thrombopoietin receptor)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41419
