MRAS (muscle RAS oncogene homolog)

2003-02-01  

Identity

HGNC
MRAS
LOCATION
3q22.3
LOCUSID
22808
ALIAS
M-RAs,NS11,R-RAS3,RRAS3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22808
MIM: 608435
HGNC: 7227
Ensembl: ENSG00000158186

Variants:

dbSNP: 22808
ClinVar: 22808
TCGA: ENSG00000158186
COSMIC: MRAS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158186ENST00000289104O14807
ENSG00000158186ENST00000289104Q6FGP0
ENSG00000158186ENST00000423968O14807
ENSG00000158186ENST00000423968Q6FGP0
ENSG00000158186ENST00000464896O14807
ENSG00000158186ENST00000474559O14807
ENSG00000158186ENST00000474559Q6FGP0
ENSG00000158186ENST00000475711C9J601
ENSG00000158186ENST00000494949C9J8Q6
ENSG00000158186ENST00000614350O14807
ENSG00000158186ENST00000621127O14807

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Autophagy - animalKEGGko04140
Regulation of actin cytoskeletonKEGGko04810
MAPK signaling pathwayKEGGhsa04010
Autophagy - animalKEGGhsa04140
Regulation of actin cytoskeletonKEGGhsa04810
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
Apelin signaling pathwayKEGGhsa04371
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA24928ARAFGenePathwayassociated
PA25408BRAFGenePathwayassociated
PA30592MAP3K1GenePathwayassociated
PA34183RAF1GenePathwayassociated
PA7360EGFRGenePathwayassociated

References

Pubmed IDYearTitleCitations
372775292023Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS.17
372775292023Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS.17
357685042022Structural basis for SHOC2 modulation of RAS signalling.8
358308822022Structure of the MRAS-SHOC2-PP1C phosphatase complex.7
358315092022Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.19
361756702022Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.11
357685042022Structural basis for SHOC2 modulation of RAS signalling.8
358308822022Structure of the MRAS-SHOC2-PP1C phosphatase complex.7
358315092022Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.19
361756702022Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.11
340807682021Atypical, severe hypertrophic cardiomyopathy in a newborn presenting Noonan syndrome harboring a recurrent heterozygous MRAS variant.4
340807682021Atypical, severe hypertrophic cardiomyopathy in a newborn presenting Noonan syndrome harboring a recurrent heterozygous MRAS variant.4
311085002020Activating MRAS mutations cause Noonan syndrome associated with hypertrophic cardiomyopathy.21
324958992020Correlation between MRAS gene polymorphism and atherosclerosis.1
311085002020Activating MRAS mutations cause Noonan syndrome associated with hypertrophic cardiomyopathy.21

Citation

Dessen P

MRAS (muscle RAS oncogene homolog)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41425/haematological-explorer/hgnc