MRAS (muscle RAS oncogene homolog)

2003-02-01  

Identity

HGNC
LOCATION
3q22.3
LOCUSID
ALIAS
M-RAs,NS11,R-RAS3,RRAS3
FUSION GENES

Other Information

Locus ID:

NCBI: 22808
MIM: 608435
HGNC: 7227
Ensembl: ENSG00000158186

Variants:

dbSNP: 22808
ClinVar: 22808
TCGA: ENSG00000158186
COSMIC: MRAS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158186ENST00000289104O14807
ENSG00000158186ENST00000289104Q6FGP0
ENSG00000158186ENST00000423968O14807
ENSG00000158186ENST00000423968Q6FGP0
ENSG00000158186ENST00000464896O14807
ENSG00000158186ENST00000474559O14807
ENSG00000158186ENST00000474559Q6FGP0
ENSG00000158186ENST00000475711C9J601
ENSG00000158186ENST00000494949C9J8Q6
ENSG00000158186ENST00000614350O14807
ENSG00000158186ENST00000621127O14807

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Autophagy - animalKEGGko04140
Regulation of actin cytoskeletonKEGGko04810
MAPK signaling pathwayKEGGhsa04010
Autophagy - animalKEGGhsa04140
Regulation of actin cytoskeletonKEGGhsa04810
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
Apelin signaling pathwayKEGGhsa04371
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA24928ARAFGenePathwayassociated
PA25408BRAFGenePathwayassociated
PA30592MAP3K1GenePathwayassociated
PA34183RAF1GenePathwayassociated
PA7360EGFRGenePathwayassociated

References

Pubmed IDYearTitleCitations
209713642010A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses.181
191986122009New susceptibility locus for coronary artery disease on chromosome 3q22.3.169
242112662013An MRAS, SHOC2, and SCRIB complex coordinates ERK pathway activation with polarity and tumorigenic growth.37
175380122007The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes.18
121382042002R-Ras3/M-Ras induces neuronal differentiation of PC12 cells through cell-type-specific activation of the mitogen-activated protein kinase cascade.16
186289882008Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease.9
207389372010Additive effect of multiple genetic variants on the risk of coronary artery disease.8
304315582019Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males.4
258004392015Genetic insight into the role of MRAS in coronary artery disease risk.2
278917602017Muscle RAS oncogene homolog (MRAS) recurrent mutation in Borrmann type IV gastric cancer.2

Citation

Dessen P

MRAS (muscle RAS oncogene homolog)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41425/mras-(muscle-ras-oncogene-homolog)