Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4547
MIM: 157147
HGNC: 7467
Ensembl: ENSG00000138823
Variants:
dbSNP: 4547
ClinVar: 4547
TCGA: ENSG00000138823
COSMIC: MTTP
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA24888 | APOA5 | Gene | Pathway | associated | |||
| PA443796 | Coronary Artery Disease | Disease | ClinicalAnnotation | associated | PD | 15136504 | |
| PA444517 | Hyperlipoproteinemia Type II | Disease | ClinicalAnnotation | associated | PD | 15864113 | |
| PA448500 | atorvastatin | Chemical | ClinicalAnnotation | associated | PD | 15864113 | |
| PA451089 | pravastatin | Chemical | ClinicalAnnotation | associated | PD | 15136504 | |
| PA50 | APOB | Gene | Pathway | associated | |||
| PA51 | APOC1 | Gene | Pathway | associated | |||
| PA52 | APOC2 | Gene | Pathway | associated | |||
| PA53 | APOC3 | Gene | Pathway | associated | |||
| PA55 | APOE | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38290649 | 2024 | Exploring the combined effects of MTTP gene polymorphisms in chronic hepatitis C patients with hepatic steatosis. | 0 |
| 38325741 | 2024 | Bulky hydrophobic side chains in the β1-sandwich of microsomal triglyceride transfer protein are critical for the transfer of both triglycerides and phospholipids. | 0 |
| 38290649 | 2024 | Exploring the combined effects of MTTP gene polymorphisms in chronic hepatitis C patients with hepatic steatosis. | 0 |
| 38325741 | 2024 | Bulky hydrophobic side chains in the β1-sandwich of microsomal triglyceride transfer protein are critical for the transfer of both triglycerides and phospholipids. | 0 |
| 36053190 | 2023 | Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion. | 3 |
| 37726765 | 2023 | Association between MTTP genotype (-493G/T) polymorphism and hepatic steatosis in hepatitis C: a systematic review and meta-analysis. | 0 |
| 36053190 | 2023 | Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion. | 3 |
| 37726765 | 2023 | Association between MTTP genotype (-493G/T) polymorphism and hepatic steatosis in hepatitis C: a systematic review and meta-analysis. | 0 |
| 36027755 | 2022 | Effect of MTTP -493G/T, I128T, Q95H and Q244E polymorphisms on hepatic steatosis in patients with chronic hepatitis. | 2 |
| 36228741 | 2022 | Microsomal triglyceride transfer protein regulates intracellular lipolysis in adipocytes independent of its lipid transfer activity. | 4 |
| 36027755 | 2022 | Effect of MTTP -493G/T, I128T, Q95H and Q244E polymorphisms on hepatic steatosis in patients with chronic hepatitis. | 2 |
| 36228741 | 2022 | Microsomal triglyceride transfer protein regulates intracellular lipolysis in adipocytes independent of its lipid transfer activity. | 4 |
| 33258201 | 2021 | A novel p.Gly417Valfs*12 mutation in the MTTP gene causing abetalipoproteinemia: Presentation of the first patient in Mexico and analysis of the previously reported cases. | 4 |
| 33924242 | 2021 | Impact of IL10, MTP, SOD2, and APOE Gene Polymorphisms on the Severity of Liver Fibrosis Induced by HCV Genotype 4. | 1 |
| 34052173 | 2021 | Normal plasma apoB48 despite the virtual absence of apoB100 in a compound heterozygote with novel mutations in the MTTP gene. | 0 |
Citation
Dessen P
MTTP (microsomal triglyceride transfer protein)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/41449/
