MUC5B (mucin 5B, oligomeric mucus/gel-forming)

2003-02-01  

Identity

HGNC
MUC5B
LOCATION
11p15.5
LOCUSID
727897
ALIAS
MG1,MUC-5B,MUC5,MUC9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 727897
MIM: 600770
HGNC: 7516
Ensembl: ENSG00000117983

Variants:

dbSNP: 727897
ClinVar: 727897
TCGA: ENSG00000117983
COSMIC: MUC5B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117983ENST00000526859H0YDX8
ENSG00000117983ENST00000529681Q9HC84

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-linked glycosylation of mucinsREACTOMER-HSA-913709
Termination of O-glycan biosynthesisREACTOMER-HSA-977068
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
Dectin-2 familyREACTOMER-HSA-5621480
Diseases associated with O-glycosylation of proteinsREACTOMER-HSA-3906995
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)REACTOMER-HSA-5083632
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)REACTOMER-HSA-5083625
Defective GALNT12 causes colorectal cancer 1 (CRCS1)REACTOMER-HSA-5083636
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378041352024Elucidating the molecular role of MUC5B in progressive lung adenocarcinoma: Prospects for early diagnosis.0
383449132024Association of MUC5B promoter polymorphism with interstitial lung changes after COVID-19: A preliminary observation.0
384625432024Hyposecretion of cervical MUC5B is related to preterm birth in pregnant women after cervical excisional surgery.0
378041352024Elucidating the molecular role of MUC5B in progressive lung adenocarcinoma: Prospects for early diagnosis.0
383449132024Association of MUC5B promoter polymorphism with interstitial lung changes after COVID-19: A preliminary observation.0
384625432024Hyposecretion of cervical MUC5B is related to preterm birth in pregnant women after cervical excisional surgery.0
359413972023Salivary film thickness and MUC5B levels at various intra-oral surfaces.1
365711112023MUC5B rs35705950 minor allele associates with older age and better survival in idiopathic pulmonary fibrosis.5
366752092023Nebulized Menthol Impairs Mucociliary Clearance via TRPM8 and MUC5AC/MUC5B in Primary Airway Epithelial Cells.2
366909262023MUC5B, telomere length and longitudinal quantitative interstitial lung changes: the MESA Lung Study.2
369124072023Are MUC5B and TERT mutations genetic risk factors for pulmonary fibrosis in individuals with severe COVID-19?1
371467372023The association between MUC5AC and MUC5B genes expression and remodeling progression in severe neutrophilic asthma: A direct relationship.3
374459252023The Presence of T Allele (rs35705950) of the MUC5B Gene Predicts Lower Baseline Forced Vital Capacity and Its Subsequent Decline in Patients with Hypersensitivity Pneumonitis.1
359413972023Salivary film thickness and MUC5B levels at various intra-oral surfaces.1
365711112023MUC5B rs35705950 minor allele associates with older age and better survival in idiopathic pulmonary fibrosis.5

Citation

Dessen P

MUC5B (mucin 5B, oligomeric mucus/gel-forming)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41461/muc5b-(mucin-5b-oligomeric-mucus-gel-forming)