MYO18B (myosin XVIIIB)

2003-02-01  

Identity

HGNC
LOCATION
22q12.1
LOCUSID
ALIAS
KFS4
FUSION GENES

Other Information

Locus ID:

NCBI: 84700
MIM: 607295
HGNC: 18150
Ensembl: ENSG00000133454

Variants:

dbSNP: 84700
ClinVar: 84700
TCGA: ENSG00000133454
COSMIC: MYO18B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133454ENST00000335473Q8IUG5
ENSG00000133454ENST00000407587Q8IUG5
ENSG00000133454ENST00000536101Q8IUG5
ENSG00000133454ENST00000539302F5H6I8
ENSG00000133454ENST00000540454A0A2Q2TCQ6
ENSG00000133454ENST00000543971H0YGQ4

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
122090132002MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer.26
125471972003Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation.22
257484842015A novel syndrome of Klippel-Feil anomaly, myopathy, and characteristic facies is linked to a null mutation in MYO18B.22
153053872004Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer.17
281047882017Myo18b is essential for sarcomere assembly in fast skeletal muscle.13
305810232019Myosin-18B Promotes the Assembly of Myosin II Stacks for Maturation of Contractile Actomyosin Bundles.8
234231382013A common variant in myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults.5
164998722006MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway.4

Citation

Dessen P

MYO18B (myosin XVIIIB)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41481/myo18b-(myosin-xviiib)