NEO1 (neogenin 1)

2003-02-01  

Identity

HGNC
NEO1
LOCATION
15q24.1
LOCUSID
4756
ALIAS
IGDCC2,NGN,NTN1R2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4756
MIM: 601907
HGNC: 7754
Ensembl: ENSG00000067141

Variants:

dbSNP: 4756
ClinVar: 4756
TCGA: ENSG00000067141
COSMIC: NEO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000067141ENST00000261908Q92859
ENSG00000067141ENST00000339362Q92859
ENSG00000067141ENST00000558964Q92859
ENSG00000067141ENST00000560262Q92859
ENSG00000067141ENST00000560328Q59FP8

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752
MyogenesisREACTOMER-HSA-525793
CDO in myogenesisREACTOMER-HSA-375170

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381568652023Hepatic Expression of NTN4 and Its Receptors in Patients with Hepatocellular Carcinoma.0
381568652023Hepatic Expression of NTN4 and Its Receptors in Patients with Hepatocellular Carcinoma.0
363615392022Netrin-1 Stimulates Migration of Neogenin Expressing Aggressive Melanoma Cells.3
363615392022Netrin-1 Stimulates Migration of Neogenin Expressing Aggressive Melanoma Cells.3
335715202021Neogenin is highly expressed in diffuse intrinsic pontine glioma and influences tumor invasion.3
338500172021Hippocampal astrocytic neogenin regulating glutamate uptake, a critical pathway for preventing epileptic response.5
335715202021Neogenin is highly expressed in diffuse intrinsic pontine glioma and influences tumor invasion.3
338500172021Hippocampal astrocytic neogenin regulating glutamate uptake, a critical pathway for preventing epileptic response.5
322313052020Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling.15
322313052020Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling.15
308584462019Loss of Neogenin1 in human colorectal carcinoma cells causes a partial EMT and wound-healing response.9
308584462019Loss of Neogenin1 in human colorectal carcinoma cells causes a partial EMT and wound-healing response.9
300641332018Neogenin-1 Promotes Cell Proliferation, Motility, and Adhesion by Up-Regulation of Zinc Finger E-Box Binding Homeobox 1 Via Activating the Rac1/PI3K/AKT Pathway in Gastric Cancer Cells.14
302221382018Inhibition of neogenin fosters resolution of inflammation and tissue regeneration.20
300641332018Neogenin-1 Promotes Cell Proliferation, Motility, and Adhesion by Up-Regulation of Zinc Finger E-Box Binding Homeobox 1 Via Activating the Rac1/PI3K/AKT Pathway in Gastric Cancer Cells.14

Citation

Dessen P

NEO1 (neogenin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41525/neo1-(neogenin-1)