NGF (nerve growth factor)

2003-05-01  

Identity

HGNC
NGF
LOCATION
1p13.2
LOCUSID
4803
ALIAS
Beta-NGF,HSAN5,NGFB

Other Information

Locus ID:

NCBI: 4803
MIM: 162030
HGNC: 7808
Ensembl: ENSG00000134259

Variants:

dbSNP: 4803
ClinVar: 4803
TCGA: ENSG00000134259
COSMIC: NGF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134259ENST00000369512P01138

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
ApoptosisKEGGko04210
MAPK signaling pathwayKEGGhsa04010
ApoptosisKEGGhsa04210
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
NGF processingREACTOMER-HSA-167060
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
NFG and proNGF binds to p75NTRREACTOMER-HSA-205017
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
NRIF signals cell death from the nucleusREACTOMER-HSA-205043
NADE modulates death signallingREACTOMER-HSA-205025
p75NTR negatively regulates cell cycle via SC1REACTOMER-HSA-193670
p75NTR signals via NF-kBREACTOMER-HSA-193639
p75NTR recruits signalling complexesREACTOMER-HSA-209543
NF-kB is activated and signals survivalREACTOMER-HSA-209560
Ceramide signallingREACTOMER-HSA-193681
p75NTR regulates axonogenesisREACTOMER-HSA-193697
Axonal growth stimulationREACTOMER-HSA-209563
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Activation of TRKA receptorsREACTOMER-HSA-187015
TRKA activation by NGFREACTOMER-HSA-187042
Signalling to ERKsREACTOMER-HSA-187687
Signalling to RASREACTOMER-HSA-167044
Signalling to p38 via RIT and RINREACTOMER-HSA-187706
Prolonged ERK activation eventsREACTOMER-HSA-169893
Frs2-mediated activationREACTOMER-HSA-170968
ARMS-mediated activationREACTOMER-HSA-170984
PLC-gamma1 signallingREACTOMER-HSA-167021
PI3K/AKT activationREACTOMER-HSA-198203
Signalling to STAT3REACTOMER-HSA-198745
Retrograde neurotrophin signallingREACTOMER-HSA-177504

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444460Heroin DependenceDiseaseClinicalAnnotationassociatedPD21358750, 23651024
PA445043Opioid-Related DisordersDiseaseClinicalAnnotationassociatedPD21358750, 23651024
PA450401methadoneChemicalClinicalAnnotationassociatedPD21358750, 23651024

References

Pubmed IDYearTitleCitations
383871912024NGF facilitates ICAM-1-dependent monocyte adhesion and M1 macrophage polarization in rheumatoid arthritis.0
384417742024Innervation pattern of the unclosed detrusor muscle in classic bladder exstrophy: a study of patients with urothelial overexpression of nerve growth factor.0
386466452024HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy.0
383871912024NGF facilitates ICAM-1-dependent monocyte adhesion and M1 macrophage polarization in rheumatoid arthritis.0
384417742024Innervation pattern of the unclosed detrusor muscle in classic bladder exstrophy: a study of patients with urothelial overexpression of nerve growth factor.0
386466452024HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy.0
365639202023NGF and BDNF in pediatrics syndromes.12
366751262023ProNGF Expression and Targeting in Glioblastoma Multiforme.4
367682812023NGF and Its Role in Immunoendocrine Communication during Metabolic Syndrome.6
370043432023Nerve growth factor mediates activation of transient receptor potential vanilloid 1 in neurogenic pruritus of psoriasis.3
371757812023Psycho-Cognitive Profile and NGF and BDNF Levels in Tears and Serum: A Pilot Study in Patients with Graves' Disease.0
375876422023Preliminary evidence that Merkel cells exert chemosensory functions in human epidermis.0
376994532023Synthesis and secretion of Nerve Growth Factor is regulated by Nitric Oxide in bladder cells in vitro under a hyperglycemic environment.0
380034272023A Vicious NGF-p75(NTR) Positive Feedback Loop Exacerbates the Toxic Effects of Oxidative Damage in the Human Retinal Epithelial Cell Line ARPE-19.0
380631172023Multidisciplinary team collaboration impact on NGF, BDNF, serum IGF-1, and life quality in patients with hemiplegia after stroke.0

Citation

Dessen P

NGF (nerve growth factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41534/cancer-prone-explorer/deep-insight-explorer/hgnc