NLGN1 (neuroligin 1)

2003-05-01   Dessen P  

Identity

HGNC
NLGN1
LOCATION
3q26.31
LOCUSID
22871
ALIAS
NL1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22871
MIM: 600568
HGNC: 14291
Ensembl: ENSG00000169760

Variants:

dbSNP: 22871
ClinVar: 22871
TCGA: ENSG00000169760
COSMIC: NLGN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169760ENST00000361589Q8N2Q7
ENSG00000169760ENST00000401917J3KQ19
ENSG00000169760ENST00000413821A0A1D5RMP7
ENSG00000169760ENST00000415045C9J4D3
ENSG00000169760ENST00000423427C9JWG7
ENSG00000169760ENST00000457714Q8N2Q7

Expression (GTEx)

0
1
2
3
4
5
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Neuronal SystemREACTOMER-HSA-112316
Protein-protein interactions at synapsesREACTOMER-HSA-6794362
Interactions of neurexins and neuroligins at synapsesREACTOMER-HSA-6794361

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375442042023Association between Neuroligin-1 polymorphism and plasma glutamine levels in individuals with autism spectrum disorder.2
375442042023Association between Neuroligin-1 polymorphism and plasma glutamine levels in individuals with autism spectrum disorder.2
355626162022Prenatal glucocorticoid exposure selectively impairs neuroligin 1-dependent neurogenesis by suppressing astrocytic FGF2-neuronal FGFR1 axis.3
360563932022The neuronal protein Neuroligin 1 promotes colorectal cancer progression by modulating the APC/β-catenin pathway.9
355626162022Prenatal glucocorticoid exposure selectively impairs neuroligin 1-dependent neurogenesis by suppressing astrocytic FGF2-neuronal FGFR1 axis.3
360563932022The neuronal protein Neuroligin 1 promotes colorectal cancer progression by modulating the APC/β-catenin pathway.9
335229672021Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for synaptic biomarkers.15
343406652021Upregulated NLGN1 predicts poor survival in colorectal cancer.8
335229672021Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for synaptic biomarkers.15
343406652021Upregulated NLGN1 predicts poor survival in colorectal cancer.8
304606782019A novel nonsense homozygous variant in the NLGN1 gene found in a pair of monozygotic twin brothers with intellectual disability and autism.4
316656292019TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering.11
318010622019Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action.16
304606782019A novel nonsense homozygous variant in the NLGN1 gene found in a pair of monozygotic twin brothers with intellectual disability and autism.4
316656292019TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering.11

Citation

Dessen P

NLGN1 (neuroligin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41543/nlgn1-(neuroligin-1)