NME2 (NME/NM23 nucleoside diphosphate kinase 2)

2003-02-01  

Identity

HGNC
NME2
LOCATION
17q21.33
LOCUSID
4831
ALIAS
NDKB,NDPK-B,NDPKB,NM23-H2,NM23B,PUF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4831
MIM: 156491
HGNC: 7850
Ensembl: ENSG00000243678

Variants:

dbSNP: 4831
ClinVar: 4831
TCGA: ENSG00000243678
COSMIC: NME2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000243678ENST00000393183F6XY72
ENSG00000243678ENST00000393190P22392
ENSG00000243678ENST00000393190Q6FHN3
ENSG00000243678ENST00000503064P22392
ENSG00000243678ENST00000503064Q6FHN3
ENSG00000243678ENST00000512737P22392
ENSG00000243678ENST00000512737Q6FHN3
ENSG00000243678ENST00000513177P22392
ENSG00000243678ENST00000513177Q6FHN3
ENSG00000243678ENST00000514264P22392
ENSG00000243678ENST00000514264Q6FHN3

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
Metabolic pathwaysKEGGhsa01100
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGhsa_M00052
Adenine ribonucleotide biosynthesis, IMP => ADP,ATPKEGGM00049
Guanine ribonucleotide biosynthesis IMP => GDP,GTPKEGGM00050
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGM00052
Adenine ribonucleotide biosynthesis, IMP => ADP,ATPKEGGhsa_M00049
Guanine ribonucleotide biosynthesis IMP => GDP,GTPKEGGhsa_M00050
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Synthesis and interconversion of nucleotide di- and triphosphatesREACTOMER-HSA-499943
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10005adefovir dipivoxilChemicalPathwayassociated
PA10204tenofovirChemicalPathwayassociated
PA450163lamivudineChemicalPathwayassociated
PA451954zidovudineChemicalPathwayassociated22960662

References

Pubmed IDYearTitleCitations
352590222022Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis.10
352590222022Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis.10
346284732021Requirement of transcription factor NME2 for the maintenance of the stemness of gastric cancer stem-like cells.9
346284732021Requirement of transcription factor NME2 for the maintenance of the stemness of gastric cancer stem-like cells.9
316949302020NME2 Is a Master Suppressor of Apoptosis in Gastric Cancer Cells via Transcriptional Regulation of miR-100 and Other Survival Factors.10
323928892020The Potential Functional Roles of NME1 Histidine Kinase Activity in Neuroblastoma Pathogenesis.18
324925012020Inosine 5'-diphosphate, a molecular decoy rescues Nucleoside diphosphate kinase from c-MYC G-Quadruplex unfolding.1
330867282020Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity.8
316949302020NME2 Is a Master Suppressor of Apoptosis in Gastric Cancer Cells via Transcriptional Regulation of miR-100 and Other Survival Factors.10
323928892020The Potential Functional Roles of NME1 Histidine Kinase Activity in Neuroblastoma Pathogenesis.18
324925012020Inosine 5'-diphosphate, a molecular decoy rescues Nucleoside diphosphate kinase from c-MYC G-Quadruplex unfolding.1
330867282020Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity.8
292517382018NM23 proteins: innocent bystanders or local energy boosters for CFTR?1
294753902018Nucleoside diphosphate kinase 2 confers acquired 5-fluorouracil resistance in colorectal cancer cells.10
296304342018Nucleoside diphosphate kinase B promotes osteosarcoma proliferation through c-Myc.7

Citation

Dessen P

NME2 (NME/NM23 nucleoside diphosphate kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41544/nme2-(nme-nm23-nucleoside-diphosphate-kinase-2)