NME4 (NME/NM23 nucleoside diphosphate kinase 4)

2003-02-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
NDPK-D,NM23H4,nm23-H4
FUSION GENES

Other Information

Locus ID:

NCBI: 4833
MIM: 601818
HGNC: 7852
Ensembl: ENSG00000103202

Variants:

dbSNP: 4833
ClinVar: 4833
TCGA: ENSG00000103202
COSMIC: NME4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103202ENST00000219479O00746
ENSG00000103202ENST00000382940Q4TT34
ENSG00000103202ENST00000397722O00746
ENSG00000103202ENST00000433358H0Y6J0
ENSG00000103202ENST00000444498F2Z2X0
ENSG00000103202ENST00000448828F2Z297
ENSG00000103202ENST00000450036O00746
ENSG00000103202ENST00000454619A2IDC9
ENSG00000103202ENST00000620944O00746
ENSG00000103202ENST00000621774A0A087WVT9

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
Metabolic pathwaysKEGGhsa01100
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGhsa_M00052
Adenine ribonucleotide biosynthesis, IMP => ADP,ATPKEGGM00049
Guanine ribonucleotide biosynthesis IMP => GDP,GTPKEGGM00050
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGM00052
Adenine ribonucleotide biosynthesis, IMP => ADP,ATPKEGGhsa_M00049
Guanine ribonucleotide biosynthesis IMP => GDP,GTPKEGGhsa_M00050
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Synthesis and interconversion of nucleotide di- and triphosphatesREACTOMER-HSA-499943

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
249700862014Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling.42
267424312016NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy.42
231506632013Dual function of mitochondrial Nm23-H4 protein in phosphotransfer and intermembrane lipid transfer: a cardiolipin-dependent switch.37
252339332014OncomiR-196 promotes an invasive phenotype in oral cancer through the NME4-JNK-TIMP1-MMP signaling pathway.33
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
290353772018NME4/nucleoside diphosphate kinase D in cardiolipin signaling and mitophagy.9
252317952015Mitochondrial NM23-H4/NDPK-D: a bifunctional nanoswitch for bioenergetics and lipid signaling.7
186047182008High expression of ERCC1, FLT1, NME4 and PCNA associated with poor prognosis and advanced stages in myelodysplastic syndrome.4
250106502014Structural comparison of highly similar nucleoside-diphosphate kinases: Molecular explanation of distinct membrane-binding behavior.2
312574882019NME4 may enhance non‑small cell lung cancer progression by overcoming cell cycle arrest and promoting cellular proliferation.0

Citation

Dessen P

NME4 (NME/NM23 nucleoside diphosphate kinase 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41546/nme4-(nme-nm23-nucleoside-diphosphate-kinase-4)