NOS2 (nitric oxide synthase 2)

Identity

HGNC

NOS2

LOCATION

17q11.2

LOCUSID

4843

ALIAS

HEP-NOS,INOS,NOS,NOS2A

FUSION GENES

Show Gene Fusions

Other Information

Locus ID:

NCBI: 4843
MIM: 163730
HGNC: 7873
Ensembl: ENSG00000007171

Variants:

dbSNP: 4843
ClinVar: 4843
TCGA: ENSG00000007171
COSMIC: NOS2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000007171	ENST00000313735	P35228
ENSG00000007171	ENST00000621962	P35228
ENSG00000007171	ENST00000646938	A0A2R8YDS4

Expression (GTEx)

0

1

2

3

4

5

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Amoebiasis	KEGG	ko05146
Amoebiasis	KEGG	hsa05146
Apelin signaling pathway	KEGG	hsa04371
Arginine and proline metabolism	KEGG	ko00330
Arginine and proline metabolism	KEGG	hsa00330
Arginine biosynthesis	KEGG	ko00220
Arginine biosynthesis	KEGG	hsa00220
Calcium signaling pathway	KEGG	ko04020
Calcium signaling pathway	KEGG	hsa04020
Chagas disease (American trypanosomiasis)	KEGG	ko05142

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA164925725	Toxic liver disease	Disease	ClinicalAnnotation	associated	PD	22341855
PA445941	Tuberculosis	Disease	ClinicalAnnotation	associated	PD	22341855
PA449412	doxorubicin	Chemical	Pathway	associated		21048526
PA449957	ibuprofen	Chemical	Pathway	associated		25502615
PA450112	isoniazid	Chemical	ClinicalAnnotation	associated	PD	22341855
PA451250	rifampin	Chemical	ClinicalAnnotation	associated	PD	22341855

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References

Pubmed ID	Year	Title	Citations
36306210	2023	Downregulation of iNOS/NO Promotes Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.	4
36394557	2023	No Association Between Interleukin 6 and Inducible Nitric Oxide Synthase Polymorphisms and Dengue Infection: A Case-Control Study.	0
36716438	2023	Female-biased association of NOS2-c.1823C>T (rs2297518) with co-susceptibility to metabolic syndrome and asthma.	0
36833440	2023	Association of Single-Nucleotide Polymorphisms Rs2779249 (chr17:26128581 C>A) and Rs rs2297518 (chr17: chr17:27769571 G>A) of the NOS2 Gene with Tension-Type Headache and Arterial Hypertension Overlap Syndrome in Eastern Siberia.	1
36863485	2023	Elevated iNOS and 3'-nitrotyrosine in Kaposi's Sarcoma tumors and mouse model.	4
37169743	2023	Interferon-gamma is quintessential for NOS2 and COX2 expression in ER(-) breast tumors that lead to poor outcome.	6
37465758	2023	Nitric oxide synthase 2 genetic variation rs2297514 associates with a decreased susceptibility to extremity post-traumatic osteomyelitis in a Chinese Han population.	0
37486100	2023	The expression levels of NOS2, HMOX1, and VEGFC in cumulus cells are markers of oocyte maturation and fertilization rate.	2
37575057	2023	Inducible nitric oxide synthase activity mediates TNF-α-induced endothelial cell dysfunction.	2
37852325	2024	NRF2 interacts with distal enhancer and inhibits nitric oxide synthase 2 expression in KRAS-driven pancreatic cancer cells.	1

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Citation

Dessen P

NOS2 (nitric oxide synthase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41553/nos2-(nitric-oxide-synthase-2)