NOS2 (nitric oxide synthase 2)

2003-06-01  

Identity

HGNC
NOS2
LOCATION
17q11.2
LOCUSID
4843
ALIAS
HEP-NOS,INOS,NOS,NOS2A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4843
MIM: 163730
HGNC: 7873
Ensembl: ENSG00000007171

Variants:

dbSNP: 4843
ClinVar: 4843
TCGA: ENSG00000007171
COSMIC: NOS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000007171ENST00000313735P35228
ENSG00000007171ENST00000621962P35228
ENSG00000007171ENST00000646938A0A2R8YDS4

Expression (GTEx)

0
1
2
3
4
5
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arginine biosynthesisKEGGko00220
Arginine and proline metabolismKEGGko00330
Calcium signaling pathwayKEGGko04020
Small cell lung cancerKEGGko05222
Arginine biosynthesisKEGGhsa00220
Arginine and proline metabolismKEGGhsa00330
Calcium signaling pathwayKEGGhsa04020
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Metabolic pathwaysKEGGhsa01100
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
PertussisKEGGko05133
PertussisKEGGhsa05133
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
HIF-1 signaling pathwayKEGGhsa04066
ROS, RNS production in phagocytesREACTOMER-HSA-1222556
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Nitric oxide stimulates guanylate cyclaseREACTOMER-HSA-392154
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164925725Toxic liver diseaseDiseaseClinicalAnnotationassociatedPD22341855
PA445941TuberculosisDiseaseClinicalAnnotationassociatedPD22341855
PA449412doxorubicinChemicalPathwayassociated21048526
PA449957ibuprofenChemicalPathwayassociated25502615
PA450112isoniazidChemicalClinicalAnnotationassociatedPD22341855
PA451250rifampinChemicalClinicalAnnotationassociatedPD22341855

References

Pubmed IDYearTitleCitations
378523252024NRF2 interacts with distal enhancer and inhibits nitric oxide synthase 2 expression in KRAS-driven pancreatic cancer cells.1
381508962024Influence of microRNAs on iNOS expression in postmortem human infarction hearts.0
385837552024INOS ablation promotes corneal wound healing via activation of Akt signaling.0
378523252024NRF2 interacts with distal enhancer and inhibits nitric oxide synthase 2 expression in KRAS-driven pancreatic cancer cells.1
381508962024Influence of microRNAs on iNOS expression in postmortem human infarction hearts.0
385837552024INOS ablation promotes corneal wound healing via activation of Akt signaling.0
363062102023Downregulation of iNOS/NO Promotes Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.4
363945572023No Association Between Interleukin 6 and Inducible Nitric Oxide Synthase Polymorphisms and Dengue Infection: A Case-Control Study.0
367164382023Female-biased association of NOS2-c.1823C>T (rs2297518) with co-susceptibility to metabolic syndrome and asthma.0
368334402023Association of Single-Nucleotide Polymorphisms Rs2779249 (chr17:26128581 C>A) and Rs rs2297518 (chr17: chr17:27769571 G>A) of the NOS2 Gene with Tension-Type Headache and Arterial Hypertension Overlap Syndrome in Eastern Siberia.1
368634852023Elevated iNOS and 3'-nitrotyrosine in Kaposi's Sarcoma tumors and mouse model.4
371697432023Interferon-gamma is quintessential for NOS2 and COX2 expression in ER(-) breast tumors that lead to poor outcome.6
374657582023Nitric oxide synthase 2 genetic variation rs2297514 associates with a decreased susceptibility to extremity post-traumatic osteomyelitis in a Chinese Han population.0
374861002023The expression levels of NOS2, HMOX1, and VEGFC in cumulus cells are markers of oocyte maturation and fertilization rate.2
375750572023Inducible nitric oxide synthase activity mediates TNF-α-induced endothelial cell dysfunction.2

Citation

Dessen P

NOS2 (nitric oxide synthase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41553/nos2-(nitric-oxide-synthase-2)