NOS2 (nitric oxide synthase 2)

2003-06-01 Affiliation

Identity

HGNC

NOS2

LOCATION

17q11.2

LOCUSID

4843

ALIAS

HEP-NOS,INOS,NOS,NOS2A

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4843
MIM: 163730
HGNC: 7873
Ensembl: ENSG00000007171

Variants:

dbSNP: 4843
ClinVar: 4843
TCGA: ENSG00000007171
COSMIC: NOS2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000007171	ENST00000313735	P35228
ENSG00000007171	ENST00000621962	P35228
ENSG00000007171	ENST00000646938	A0A2R8YDS4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Arginine biosynthesis	KEGG	ko00220
Arginine and proline metabolism	KEGG	ko00330
Calcium signaling pathway	KEGG	ko04020
Small cell lung cancer	KEGG	ko05222
Arginine biosynthesis	KEGG	hsa00220
Arginine and proline metabolism	KEGG	hsa00330
Calcium signaling pathway	KEGG	hsa04020
Pathways in cancer	KEGG	hsa05200
Small cell lung cancer	KEGG	hsa05222
Peroxisome	KEGG	ko04146
Peroxisome	KEGG	hsa04146
Metabolic pathways	KEGG	hsa01100
Leishmaniasis	KEGG	ko05140
Leishmaniasis	KEGG	hsa05140
Chagas disease (American trypanosomiasis)	KEGG	ko05142
Chagas disease (American trypanosomiasis)	KEGG	hsa05142
Amoebiasis	KEGG	ko05146
Amoebiasis	KEGG	hsa05146
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Pertussis	KEGG	ko05133
Pertussis	KEGG	hsa05133
Salmonella infection	KEGG	ko05132
Salmonella infection	KEGG	hsa05132
HIF-1 signaling pathway	KEGG	hsa04066
ROS, RNS production in phagocytes	REACTOME	R-HSA-1222556
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Hemostasis	REACTOME	R-HSA-109582
Platelet homeostasis	REACTOME	R-HSA-418346
Nitric oxide stimulates guanylate cyclase	REACTOME	R-HSA-392154
Interleukin-4 and 13 signaling	REACTOME	R-HSA-6785807
Apelin signaling pathway	KEGG	hsa04371

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA164925725	Toxic liver disease	Disease	ClinicalAnnotation	associated	PD	22341855
PA445941	Tuberculosis	Disease	ClinicalAnnotation	associated	PD	22341855
PA449412	doxorubicin	Chemical	Pathway	associated		21048526
PA449957	ibuprofen	Chemical	Pathway	associated		25502615
PA450112	isoniazid	Chemical	ClinicalAnnotation	associated	PD	22341855
PA451250	rifampin	Chemical	ClinicalAnnotation	associated	PD	22341855

References

Pubmed ID	Year	Title	Citations
20438856	2010	Regulation of the expression of inducible nitric oxide synthase.	138
21729780	2011	Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2.	117
20953189	2010	Genome-wide association analysis identifies three psoriasis susceptibility loci.	106
17703412	2007	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	100
26335399	2015	The dual role of iNOS in cancer.	92
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
20978357	2010	Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients.	85
16352737	2005	A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis.	78
17720813	2007	NOS2 regulation of NF-kappaB by S-nitrosylation of p65.	77
16260491	2005	Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase.	69

Citation

Dessen P

NOS2 (nitric oxide synthase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41553/nos2-(nitric-oxide-synthase-2)