Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4855
MIM: 164951
HGNC: 7884
Ensembl: ENSG00000204301
Variants:
dbSNP: 4855
ClinVar: 4855
TCGA: ENSG00000204301
COSMIC: NOTCH4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000204301 | ENST00000375023 | Q99466 |
| ENSG00000204301 | ENST00000375023 | A0A1U9X983 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166120929 | severe cutaneous adverse reactions | Disease | ClinicalAnnotation | associated | PD | 29193002 | |
| PA448320 | allopurinol | Chemical | ClinicalAnnotation | associated | PD | 29193002 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38811818 | 2024 | Inhibition of NOTCH4 sensitizes FLT3/ITD acute myeloid leukemia cells to FLT3 tyrosine kinase inhibition. | 0 |
| 38811818 | 2024 | Inhibition of NOTCH4 sensitizes FLT3/ITD acute myeloid leukemia cells to FLT3 tyrosine kinase inhibition. | 0 |
| 36724752 | 2023 | NOTCH4 Single-Nucleotide Polymorphism Is Associated with Brain Arteriovenous Malformation in a Chinese Han Population. | 1 |
| 36817473 | 2023 | Polymorphisms and gene expression of Notch4 in pulmonary tuberculosis. | 0 |
| 37268635 | 2023 | NOTCH4(ΔL12_16) sensitizes lung adenocarcinomas to EGFR-TKIs through transcriptional down-regulation of HES1. | 0 |
| 37478314 | 2023 | NOTCH4 potentiates the IL-13 induced genetic program in M2 alternative macrophages through the AP1 and IRF4-JMJD3 axis. | 2 |
| 37544578 | 2023 | Association of NOTCH4 and ACHE gene polymorphism in Alzheimer's disease of Gujarat cohort. | 0 |
| 36724752 | 2023 | NOTCH4 Single-Nucleotide Polymorphism Is Associated with Brain Arteriovenous Malformation in a Chinese Han Population. | 1 |
| 36817473 | 2023 | Polymorphisms and gene expression of Notch4 in pulmonary tuberculosis. | 0 |
| 37268635 | 2023 | NOTCH4(ΔL12_16) sensitizes lung adenocarcinomas to EGFR-TKIs through transcriptional down-regulation of HES1. | 0 |
| 37478314 | 2023 | NOTCH4 potentiates the IL-13 induced genetic program in M2 alternative macrophages through the AP1 and IRF4-JMJD3 axis. | 2 |
| 37544578 | 2023 | Association of NOTCH4 and ACHE gene polymorphism in Alzheimer's disease of Gujarat cohort. | 0 |
| 35543859 | 2022 | Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is synergistically associated with T cell exclusion, immune checkpoint blockade efficacy and recurrence risk in ER-negative breast cancer. | 8 |
| 35967450 | 2022 | NOTCH4 mutation as predictive biomarker for immunotherapy benefits in NRAS wildtype melanoma. | 4 |
| 36044575 | 2022 | JAG1-NOTCH4 mechanosensing drives atherosclerosis. | 6 |
Citation
Dessen P
NOTCH4 (notch receptor 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41558
