NOX4 (NADPH oxidase 4)

2003-05-01  

Identity

HGNC
NOX4
LOCATION
11q14.3
LOCUSID
50507
ALIAS
KOX,KOX-1,RENOX
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 50507
MIM: 605261
HGNC: 7891
Ensembl: ENSG00000086991

Variants:

dbSNP: 50507
ClinVar: 50507
TCGA: ENSG00000086991
COSMIC: NOX4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000086991ENST00000263317Q9NPH5
ENSG00000086991ENST00000343727Q9NPH5
ENSG00000086991ENST00000375979Q9NPH5
ENSG00000086991ENST00000393282Q9NPH5
ENSG00000086991ENST00000424319Q9NPH5
ENSG00000086991ENST00000525196E9PI95
ENSG00000086991ENST00000527626E9PR43
ENSG00000086991ENST00000527956Q9NPH5
ENSG00000086991ENST00000528341E9PPP2
ENSG00000086991ENST00000529343Q9NPH5
ENSG00000086991ENST00000531342Q9NPH5
ENSG00000086991ENST00000532825Q9NPH5
ENSG00000086991ENST00000534731Q9NPH5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685

References

Pubmed IDYearTitleCitations
373681562024DKK3 promotes oxidative stress injury and fibrosis in HK-2 cells by activating NOX4 via β-catenin/TCF4 signaling.0
379899202024NADPH oxidase 4-mediating oxidative stress contributes to endometriosis.0
380923012024NOX4 alleviates breast cancer cell aggressiveness by co-ordinating mitochondrial turnover through PGC1α/Drp1 axis.0
383409452024CircSTRBP contributes to H(2)O(2)-induced lens epithelium cell dysfunction through increasing NOX4 mRNA stability by recruiting IGF2BP1.0
383480422024Development and validation of a new diagnostic prediction model of ENHO and NOX4 for early diagnosis of systemic sclerosis.0
383790952024Rare coding variants in NOX4 link high ROS levels to psoriatic arthritis mutilans.0
383872812024Tumor-associated macrophage (TAM)-secreted CCL22 confers cisplatin resistance of esophageal squamous cell carcinoma (ESCC) cells via regulating the activity of diacylglycerol kinase α (DGKα)/NOX4 axis.0
385935052024NOX4 regulates gastric cancer cell invasion and proliferation by increasing ferroptosis sensitivity through regulating ROS.0
386639132024Comprehensive bioinformatics analysis of NOX4 as a biomarker for pan-cancer prognosis and immune infiltration.0
386909392024NADPH oxidase 4-derived hydrogen peroxide counterbalances testosterone-induced endothelial dysfunction and migration.0
373681562024DKK3 promotes oxidative stress injury and fibrosis in HK-2 cells by activating NOX4 via β-catenin/TCF4 signaling.0
379899202024NADPH oxidase 4-mediating oxidative stress contributes to endometriosis.0
380923012024NOX4 alleviates breast cancer cell aggressiveness by co-ordinating mitochondrial turnover through PGC1α/Drp1 axis.0
383409452024CircSTRBP contributes to H(2)O(2)-induced lens epithelium cell dysfunction through increasing NOX4 mRNA stability by recruiting IGF2BP1.0
383480422024Development and validation of a new diagnostic prediction model of ENHO and NOX4 for early diagnosis of systemic sclerosis.0

Citation

Dessen P

NOX4 (NADPH oxidase 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41562/nox4-(nadph-oxidase-4)